UBA6

Gene Symbol	UBA6
Entrez Gene	55236
Alt Symbol	E1-L2, MOP-4, UBE1L2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 6
Other Description	UBA6, ubiquitin-activating enzyme E1|monocyte protein 4|ubiquitin-activating enzyme 6|ubiquitin-activating enzyme E1-like 2|ubiquitin-activating enzyme E1-like protein 2|ubiquitin-like modifier-activating enzyme 6
Swissprots	Q9H3T7 Q8N9E4 Q86TC7 A0AVT1 Q8N5T3 Q9NVC9 B2RAV3 Q4W5K0 Q86T78 A6N8M7 Q6UV21
Accessions	A0AVT1 AAY40999 EAX05549 EAX05550 EAX05551 EAX05552 EAX05553 AB014773 BAB19785 AK001670 BAA91824 AK027020 AK094164 BAG52833 AK094969 BAC04463 AK314371 BAG37000 AL596839 AL832015 CAD89908 AL832458 CAD89959 AM392673 CAL37551 AW451445 AY359880 AAQ63403 BC031637 AAH31637 BC126484 AAI26485 BC126486 AAI26487 BM973988 EF623993 ABR25253 XM_011532082 XP_011530384 NM_018227 NP_060697
Function	Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673}.
Tissue Specificity	Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Uba6 full length protein - ab188675 from Abcam Category Protein Prices $572.00 Sizes 25 µg Source Baculovirus infected sf9 cells Species Human

Human Uba6 full length protein - ab157040 from Abcam Category Protein Source Baculovirus Species Human

Human Uba6 full length protein - ab163029 from Abcam Category Protein Source Wheat germ Species Human

Human Uba6 full length protein - ab163030 from Abcam Category Protein Source Wheat germ Species Human

Human Uba6 full length protein - ab90022 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Uba6 protein fragment - ab163031 from Abcam Category Protein Source Wheat germ Species Human

UBE1L2 / UBE1L2 Antibody Blocking Peptide - LS-E4545 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE1L2 / UBE1L2 Antibody Blocking Peptide - LS-E21721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FLJ10808 Protein - H00055236-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FLJ10808 Protein - H00055236-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FLJ10808 Recombinant Protein - H00055236-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UBA6-Antibody-C-term-Blocking-Peptide - BP16886b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human GST-Ubiquitin E1 Enzyme (UBE1L2/UBA6), CF - E-307-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 9 (baculovirus)-derived, Contains an N-terminal GST (glutathione S-transferase) tag

UBA6 Blocking Peptide - 33R-2792 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBA6 / MOP4 - H00055236-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBA6 / MOP4 - H00055236-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBA6 / MOP4 - H00055236-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

UBA6 / MOP4 - H00055236-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBA6 / MOP4 - H00055236-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBA6 / MOP4 - H00055236-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBA6 / MOP4 - H00055236-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBA6 fusion protein - Ag4000 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

UBA6 (UBE1L2), Active Human Recombinant Protein - GWB-CA6D99 from Genway Biotech Category Protein Prices $392.00 Sizes 100 µg Species Human

Recombinant Rat Vascular Endothelial Growth Factor A - UBA6-46H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cell .

Recombinant Human UBA6, GST-tagged - UBA6-2440H from Creative Biomart Category Protein Source E. coli .

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