ITGB3

Gene Symbol	ITGB3
Entrez Gene	3690
Alt Symbol	BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Species	Human
Gene Type	protein-coding
Description	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Other Description	integrin beta-3|platelet membrane glycoprotein IIIa
Swissprots	Q13413 D3DXJ8 Q14648 P05106 Q12806 A0PJW2 O15495 Q16499
Accessions	AAA16076 AAA20880 AAA52600 AAA67537 AAB23689 AAV29938 ABE67092 ABS86940 ADZ28534 ADZ28535 ADZ28536 ADZ28537 ADZ28538 ADZ28539 ADZ76019 ADZ76020 AGC82918 AGC82919 AGG40669 AHV90406 EAW57679 EAW57680 EAW57681 EAW57682 P05106 AY826979 AAX33645 BC127666 AAI27667 BC127667 AAI27668 BE389074 BE893993 BG170864 BQ437000 J02703 AAA52589 KC120777 AGC54783 KC120778 AGC54784 M20311 AAA60122 M25108 AAA36121 M35999 AAA35927 S70348 AAB30847 U95204 AAB71380 NM_000212 NP_000203
Function	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single- pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
Tissue Specificity	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Top Pathways	Phagosome, MicroRNAs in cancer, Rap1 signaling pathway, Proteoglycans in cancer, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Platelet Glycoprotein IIb + IIIa Human ELISA Kit - ab108851 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 1 ng/ml Range 1.25 ng/ml - 40 ng/ml

Human ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Sandwich ELISA) - LS-F6638 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.781-50 ng/ml

Mouse/Human ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Cell-Based ELISA) - LS-F2083 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.781-50 ng/ml

Mouse/Human/Rat Phospho-ITGB3 / Integrin Beta 3 / CD61 (Tyr773) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1538 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.781-50 ng/ml

Mouse/Human/Rat Phospho-ITGB3 / Integrin Beta 3 / CD61 (Tyr785) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1539 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.781-50 ng/ml

Mouse ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Sandwich ELISA) - LS-F8502 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 31.2 pg/ml Range 0.781-50 ng/ml

Integrin Beta 3 (ITGb3), Human, ELISA Kit - SEB262Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 13.3pg/mL Range 31.2-2,000pg/mL

Integrin beta-3 (ITGB3), Human, ELISA Kit - CSB-EL011885HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

ITGB3, ELISA Kit - MBS2515789 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

ITGB3, ELISA Kit - MBS2516199 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Integrin beta3 Colorimetric Cell-Based ELISA Kit - CB5371 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Integrin beta3 (Phospho-Tyr773) Colorimetric Cell-Based ELISA Kit - CBP1586 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Integrin beta3 (Phospho-Tyr785) Colorimetric Cell-Based ELISA Kit - CBP1587 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Integrin Beta 3 (ITGb3), ELISA Kit - MBS2019702 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.31ng/mL. Range 0.781-50ng/mL

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) , ELISA Kit - MBS944918 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

ELISA Kit for Integrin Beta 3 (ITGb3) - SEB262Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

ELISA Kit for Integrin Beta 3 (ITGb3) - SEB262Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.5pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human Integrin beta-3(ITGB3) ELISA kit - CSB-EL011885HU from Cusabio Category ELISA Kit Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

ELISA Kit for Integrin Beta 3 (ITGb3) - SEB262Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Custom ELISA) - LS-F17786 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.781-50 ng/ml

Mouse ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Custom ELISA) - LS-F17787 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.781-50 ng/ml

Integrin Beta 3 (ITGb3), ELISA Kit - MBS2024149 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse ITGb3 is typically less than 13.5pg/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 31.2-2,000pg/mL

Human GP?b/?a(Platelet Membrane Glycoprotein ?b/?a complex) ELISA Kit - E-EL-H2203 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human Integrin beta-3 ELISA Kit - abx251057 from Abbexa Category ELISA Kit Range 0.078 ng/ml - 5 ng/ml

Mouse ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Sandwich ELISA) - LS-F23527 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 18.75 pg/ml Range 0.781-50 ng/ml

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