ITGB3

Gene Symbol	ITGB3
Entrez Gene	3690
Alt Symbol	BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Species	Human
Gene Type	protein-coding
Description	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Other Description	integrin beta-3|platelet membrane glycoprotein IIIa
Swissprots	Q13413 D3DXJ8 Q14648 P05106 Q12806 A0PJW2 O15495 Q16499
Accessions	AAA16076 AAA20880 AAA52600 AAA67537 AAB23689 AAV29938 ABE67092 ABS86940 ADZ28534 ADZ28535 ADZ28536 ADZ28537 ADZ28538 ADZ28539 ADZ76019 ADZ76020 AGC82918 AGC82919 AGG40669 AHV90406 EAW57679 EAW57680 EAW57681 EAW57682 P05106 AY826979 AAX33645 BC127666 AAI27667 BC127667 AAI27668 BE389074 BE893993 BG170864 BQ437000 J02703 AAA52589 KC120777 AGC54783 KC120778 AGC54784 M20311 AAA60122 M25108 AAA36121 M35999 AAA35927 S70348 AAB30847 U95204 AAB71380 NM_000212 NP_000203
Function	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single- pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
Tissue Specificity	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Top Pathways	Phagosome, MicroRNAs in cancer, Rap1 signaling pathway, Proteoglycans in cancer, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Integrin beta 3/CD61 (NP_000203) VersaClone cDNA - RDC0399 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

ITGB3 - MBS1275023 from MyBioSource Species Human Accession BC127666

Human ITGB3 cDNA clone(NM_000212.2) - CDFH009453 from Creative Biomart Species Human Accession NM_000212.2

Human ITGB3 ORF Clone(NM_000212.2) - CDCR279199 from Creative Biomart Species Human Accession NM_000212.2

Human ITGB3 ORF Clone(NM_000212.2) - CDCR279200 from Creative Biomart Species Human Accession NM_000212.2

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone in cloning vector - HG10787-M from Sino Biological Species Human

Human Integrin beta3 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-tagged - HG10787-ACG from Sino Biological Species Human Accession NM_000212.2

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10787-NF from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10787-NM from Sino Biological Species Human

Human Integrin beta3 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10787-M-F from Sino Biological Species Human Accession NM_000212.2

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10787-CF from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10787-CY from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-His tag - HG10787-NH from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10787-CM from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10787-NY from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-His tag - HG10787-CH from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10787-ACR from Sino Biological Species Human

Human CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid - HG10787-UT from Sino Biological Species Human

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-Myc tag - CG90309-CM from Sino Biological Species Monkey

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid - CG90309-UT from Sino Biological Species Monkey

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-His tag - CG90309-NH from Sino Biological Species Monkey

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-His tag - CG90309-CH from Sino Biological Species Monkey

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, N-HA tag - CG90309-NY from Sino Biological Species Monkey

Rhesus CD61/Integrin beta 3/ITGB3 Gene ORF cDNA clone expression plasmid, C-HA tag - CG90309-CY from Sino Biological Species Monkey

Mouse Integrin beta 3/CD61 (NP_058060) VersaClone cDNA - RDC1418 from R&D Systems Prices $499.00 Sizes 10 µg Species Mouse

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