ITGB3

Gene Symbol	ITGB3
Entrez Gene	3690
Alt Symbol	BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Species	Human
Gene Type	protein-coding
Description	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Other Description	integrin beta-3|platelet membrane glycoprotein IIIa
Swissprots	Q13413 D3DXJ8 Q14648 P05106 Q12806 A0PJW2 O15495 Q16499
Accessions	AAA16076 AAA20880 AAA52600 AAA67537 AAB23689 AAV29938 ABE67092 ABS86940 ADZ28534 ADZ28535 ADZ28536 ADZ28537 ADZ28538 ADZ28539 ADZ76019 ADZ76020 AGC82918 AGC82919 AGG40669 AHV90406 EAW57679 EAW57680 EAW57681 EAW57682 P05106 AY826979 AAX33645 BC127666 AAI27667 BC127667 AAI27668 BE389074 BE893993 BG170864 BQ437000 J02703 AAA52589 KC120777 AGC54783 KC120778 AGC54784 M20311 AAA60122 M25108 AAA36121 M35999 AAA35927 S70348 AAB30847 U95204 AAB71380 NM_000212 NP_000203
Function	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single- pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
Tissue Specificity	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Top Pathways	Phagosome, MicroRNAs in cancer, Rap1 signaling pathway, Proteoglycans in cancer, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITGB3 / Integrin Beta 3 / CD61 Antibody Blocking Peptide - LS-E23198 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITGB3 / Integrin Beta 3 / CD61 Antibody Blocking Peptide - LS-E9713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITGB3 / Integrin Beta 3 / CD61 Antibody Blocking Peptide - LS-E29641 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGB3 / Integrin Beta 3 / CD61 Antibody Blocking Peptide - LS-E29642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGB3-Antibody-C-term-Blocking-Peptide - BP8672b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD61 Blocking Peptide - abx062811 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep

CD61 Blocking Peptide - abx062812 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep

Human Integrin Beta 3 Protein - abx067293 from Abbexa Category Protein Source E.coli Species Human

Integrin Beta 3 (ITGb3), Human - 20-7604 from ARP American Research Products Category Protein Prices $389.00 Sizes 50 µg Source E.coli Species Human

ITGB3 fusion protein - ag18881 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ITGB3 fusion protein - ag18700 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Fibrinogen-binding Peptide - 350173 from ABBIOTEC Category Peptide Prices $138.00 Sizes 10 mg

CD61 Peptide - 350573 from ABBIOTEC Category Peptide Prices $80.00 Sizes 100 µg

Integrin -beta3 (Phospho-Tyr773) Antibody Blocking Peptide - GWB-7382F4 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Native Human GPIIbIIIa - ITGB3-11H from Creative Biomart Category Protein Source Human plasma Species Human

Recombinant Integrin Beta 3 (ITGb3) - RPB262Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Integrin Beta 3 (ITGb3) - RPB262Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Integrin Beta 3 (ITGb3) - RPB262Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Integrin Beta 3 (ITGb3) - RPB262Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

CD61 Blocking Peptide - CBP1617 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep

CD61 Blocking Peptide - CBP1618 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep

CD61 (pY773) Blocking Peptide - CBP4041 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep

Integrin β3 (T767) Peptide - BS1187P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Integrin β3 (S778) Peptide - BS3660P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Integrin β3 (Y773) Peptide - BS4103P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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