| Gene Symbol |
ITGB3
|
| Entrez Gene |
3690
|
| Alt Symbol |
BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
|
| Other Description |
integrin beta-3|platelet membrane glycoprotein IIIa
|
| Swissprots |
Q13413 D3DXJ8 Q14648 P05106 Q12806 A0PJW2 O15495 Q16499
|
| Accessions |
AAA16076 AAA20880 AAA52600 AAA67537 AAB23689 AAV29938 ABE67092 ABS86940 ADZ28534 ADZ28535 ADZ28536 ADZ28537 ADZ28538 ADZ28539 ADZ76019 ADZ76020 AGC82918 AGC82919 AGG40669 AHV90406 EAW57679 EAW57680 EAW57681 EAW57682 P05106 AY826979 AAX33645 BC127666 AAI27667 BC127667 AAI27668 BE389074 BE893993 BG170864 BQ437000 J02703 AAA52589 KC120777 AGC54783 KC120778 AGC54784 M20311 AAA60122 M25108 AAA36121 M35999 AAA35927 S70348 AAB30847 U95204 AAB71380 NM_000212 NP_000203
|
| Function |
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sa
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single- pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
|
| Tissue Specificity |
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
|
| Top Pathways |
Phagosome, MicroRNAs in cancer, Rap1 signaling pathway, Proteoglycans in cancer, PI3K-Akt signaling pathway
|
