NTRK1

Gene Symbol	NTRK1
Entrez Gene	4914
Alt Symbol	MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Species	Human
Gene Type	protein-coding
Description	neurotrophic tyrosine kinase, receptor, type 1
Other Description	Oncogene TRK|TRK1-transforming tyrosine kinase protein|gp140trk|high affinity nerve growth factor receptor|tropomyosin-related kinase A|tyrosine kinase receptor A
Swissprots	Q7Z5C3 Q5VZS2 P04629 Q5D056 B7ZM34 Q15655 Q9UIU7 P08119 B2R6T5
Accessions	AAP88292 BAA34355 CDI70969 EAW52900 EAW52901 EAW52902 P04629 AK126428 AK290759 BAF83448 AK312704 BAG35582 BC062580 AAH62580 BC136554 AAI36555 BC144239 AAI44240 BM685020 CR936794 KJ534902 AHW56542 KJ534903 AHW56543 M23102 AAA36770 NM_001007792 NP_001007793 NM_001012331 NP_001012331 NM_002529 NP_002520
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15488758}; Single-pass type I membrane protein {ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}.
Top Pathways	Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NTRK1 overexpression lysate - LY400383 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

NTRK1 overexpression lysate - LY419273 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

NTRK1 293 Cell Lysate - 400409 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

NTRK1 293 Cell Lysate - 409031 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

NTRK1 293 Cell Lysate - 409908 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

TrkA Overexpression Lysate (Native) - NBL1-13834 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

TrkA Overexpression Lysate (Native) - NBL1-13835 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

TrkA Overexpression Lysate (Native) - NBL1-13833 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

NTRK1 Over-expression Lysate Product - GWB-953750 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

NTRK1 Over-expression Lysate Product - GWB-6F914B from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

NTRK1 Over-expression Lysate Product - GWB-6534A4 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human TrkA / NTRK1 HEK293 Cell Lysate (WB positive control) - 11073-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TrkA / NTRK1 (aa 194-413) HEK293 Cell Lysate (WB positive control) - 11073-H07H2L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TrkA / NTRK1 HEK293 Cell Lysate (WB positive control) - 11073-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TrkA Human Cells Transfected Lysate (positive control) (denatured) - orb173149 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human TrkA Human Cells Transfected Lysate (positive control) (denatured) - orb173603 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human TrkA Human Cells Transfected Lysate (positive control) (denatured) - orb173148 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human NTRK1 Knockdown Stable Cell Line - CSC-DC010682 from Creative biogene Category Cell Line Species Human

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