NTRK1

Gene Symbol NTRK1
Entrez Gene 4914
Alt Symbol MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Species Human
Gene Type protein-coding
Description neurotrophic tyrosine kinase, receptor, type 1
Other Description Oncogene TRK|TRK1-transforming tyrosine kinase protein|gp140trk|high affinity nerve growth factor receptor|tropomyosin-related kinase A|tyrosine kinase receptor A
Swissprots Q7Z5C3 Q5VZS2 P04629 Q5D056 B7ZM34 Q15655 Q9UIU7 P08119 B2R6T5
Accessions AAP88292 BAA34355 CDI70969 EAW52900 EAW52901 EAW52902 P04629 AK126428 AK290759 BAF83448 AK312704 BAG35582 BC062580 AAH62580 BC136554 AAI36555 BC144239 AAI44240 BM685020 CR936794 KJ534902 AHW56542 KJ534903 AHW56543 M23102 AAA36770 NM_001007792 NP_001007793 NM_001012331 NP_001012331 NM_002529 NP_002520
Function Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location Cell membrane {ECO:0000269|PubMed:15488758}; Single-pass type I membrane protein {ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). {ECO:0000250}.
Tissue Specificity Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}.
Top Pathways Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

SignalSilence ® TrkA siRNA I - 6613 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from SMS-KCN cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-) or SignalSilence ® TrkA siRNA I (+), using TrkA (14G6) Rabbit mAb #2508 (upper) or α-Tubulin (11H10) Rabbit mAb #2125 (lower). The TrkA (14G6) Rabbit mAb confirms silencing of TrkA expression, while the α-Tubulin (11H10) Rabbit mAb is used as a loading control.

Trk A CRISPR/Cas9 KO Plasmid (h) - sc-400188 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A HDR Plasmid (h) - sc-400188-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A Double Nickase Plasmid (h) - sc-400188-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A Double Nickase Plasmid (h2) - sc-400188-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A CRISPR Activation Plasmid (h) - sc-400188-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A CRISPR Activation Plasmid (h2) - sc-400188-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A Lentiviral Activation Particles (h) - sc-400188-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk A Lentiviral Activation Particles (h2) - sc-400188-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Trk siRNA (h) - sc-29511 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Trk shRNA Plasmid (h) - sc-29511-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Trk shRNA (h) Lentiviral Particles - sc-29511-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Trk A siRNA (h) - sc-36726 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Trk A shRNA Plasmid (h) - sc-36726-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Trk A shRNA (h) Lentiviral Particles - sc-36726-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TrkA RNAi - H00004914-R11 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TrkA RNAi - H00004914-R10 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU081661 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1456 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1457 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1458 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN15569 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15569 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00445 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00445

NTRK1 siRNA (Human) - CRH3265 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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