NTRK1

Gene Symbol NTRK1
Entrez Gene 4914
Alt Symbol MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Species Human
Gene Type protein-coding
Description neurotrophic tyrosine kinase, receptor, type 1
Other Description Oncogene TRK|TRK1-transforming tyrosine kinase protein|gp140trk|high affinity nerve growth factor receptor|tropomyosin-related kinase A|tyrosine kinase receptor A
Swissprots Q7Z5C3 Q5VZS2 P04629 Q5D056 B7ZM34 Q15655 Q9UIU7 P08119 B2R6T5
Accessions AAP88292 BAA34355 CDI70969 EAW52900 EAW52901 EAW52902 P04629 AK126428 AK290759 BAF83448 AK312704 BAG35582 BC062580 AAH62580 BC136554 AAI36555 BC144239 AAI44240 BM685020 CR936794 KJ534902 AHW56542 KJ534903 AHW56543 M23102 AAA36770 NM_001007792 NP_001007793 NM_001012331 NP_001012331 NM_002529 NP_002520
Function Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location Cell membrane {ECO:0000269|PubMed:15488758}; Single-pass type I membrane protein {ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). {ECO:0000250}.
Tissue Specificity Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}.
Top Pathways Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb - 4168 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C67C8
Western blot analysis of extracts from NIH/3T3 cells transfected with TrkB, untreated or treated with hBDNF #3897, using Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb (upper) and Trk (pan) (C17F1) Rabbit mAb #4609 (lower).

Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb - 4621 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C50F3
Western blot analysis of extracts from NIH/3T3 cells stably transfected with TrkA or TrkB, and treated with NGF or BDNF, respectively, using Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb (upper) and pooled TrkA/TrkB Antibodies (lower).

Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb - 4619 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C35G9
Western blot analysis of extracts from NIH/3T3 cells stably transfected with either TrkA or TrkB, left untreated or treated with NGF or BDNF, respectively, using Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb (upper) and pooled TrkA/TrkB antibodies (lower).

Phospho-TrkA (Tyr490) Antibody - 9141 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PC12 cells, untreated or NGF-treated (100 ng/ml), using Phospho-TrkA (Tyr490) Antibody.

Trk (pan) (C17F1) Rabbit mAb - 4609 from Cell Signaling Technology

Prices $129.00, $239.00
Sizes 40 µl (4 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C17F1
Western blot analysis of extracts from fetal human brain and mouse brain using Trk (pan) (C17F1) Rabbit mAb.

TrkA (14G6) Rabbit mAb - 2508 from Cell Signaling Technology

Prices $129.00, $239.00
Sizes 40 µl (4 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 14G6
Western blot analysis of extracts from NIH/3T3, NIH/3T3-TrkA, NIH/3T3-TrkB and NIH/3T3-TrkC and K562 cells using TrkA (14G6) Rabbit mAb (upper) TrkB (80G2) Rabbit mAb Antibody #4607 (middle) and PLCγ1 Antibody #2822 (lower).

TrkA Antibody - 2505 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis from various cell lysates and rat brain cell extracts, using TrkA Antibody.

PhosphoPlus® TrkA (Tyr490, 674/675) Antibody Kit - 9140 from Cell Signaling Technology

Clonality Polyclonal

Phospho-TrkA (Tyr674/675) Antibody - 9144 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

TrkA Antibody - 9142 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Trk (B-3) - sc-7268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Trk (B-3): sc-7268. Western blot analysis of Trk expression in PC-12 (A), H4 (B), SK-N-SH (C) and U-87 (D) whole cell lysates.

Trk (C-14) - sc-11 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk (C-14): sc-11. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skin tissue showing membrane staining.

Trk A (763) - sc-118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk A (763): sc-118. Western blot analysis of Trk A expression in PC-12 (A), H4 (B) and SK-N-SH (C) whole cell lysates.

Trk A (C-20) - sc-20539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Trk A (C-20): sc-20539. Western blot analysis of Trk A expression in PC-12 whole cell lysate.

Trk A (H-190) - sc-14024 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trk A (H-190): sc-14024. Western blot analysis of human recombinant Trk A fusion protein.

Trk A (N-20) - sc-20537 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Trk A (N-20): sc-20537. Western blot analysis of Trk A expression in SH-SY5Y whole cell lysate.

Trk A (Y32Ex) - sc-80398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Trk A (H10) - sc-80961 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal

p-Trk (Tyr 680/Tyr 681) - sc-7996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Trk (Tyr 680/Tyr 681)-R: sc-7996-R. Western blot analysis of Trk phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.

p-Trk (Tyr 496) - sc-7987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Trk (Tyr 496)-R: sc-7987-R. Western blot analysis of Trk phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.

p-Trk (E-6) - sc-8058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Trk activation in untreated (A,C) and γ-interferon-induced (B,D) RAW 264.7 cells. Antibodies tested include a phospho-specific Trk monoclonal, p-Trk (E-6): sc-8058 (A,B) and a control antibody, Trk (B-3): sc-7268 (C,D).

Anti-Pan Trk antibody - ab79770 from Abcam

Prices $370.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TrkA (phospho Y490) antibody - ab1445 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TrkA (phospho Y490) antibody - ab85130 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TrkA (phospho Y490) antibody (ab85130) at 1 µg/mlLane 1 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell Lysate Lane 2 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell Lysate with Human TrkA (phospho Y490) peptide (ab99483) at 1 µg/mlLane 3 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell Lysate with TrkA peptide (ab116686) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TrkA (phospho Y496) antibody - ab111606 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111606 at 1/100 dilution staining TrkA in NIH3T3 cells by Immunofluorescence. The picture on the right is treated with the synthesized phosphopeptide.
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