NTRK1

Gene Symbol	NTRK1
Entrez Gene	4914
Alt Symbol	MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Species	Human
Gene Type	protein-coding
Description	neurotrophic tyrosine kinase, receptor, type 1
Other Description	Oncogene TRK|TRK1-transforming tyrosine kinase protein|gp140trk|high affinity nerve growth factor receptor|tropomyosin-related kinase A|tyrosine kinase receptor A
Swissprots	Q7Z5C3 Q5VZS2 P04629 Q5D056 B7ZM34 Q15655 Q9UIU7 P08119 B2R6T5
Accessions	AAP88292 BAA34355 CDI70969 EAW52900 EAW52901 EAW52902 P04629 AK126428 AK290759 BAF83448 AK312704 BAG35582 BC062580 AAH62580 BC136554 AAI36555 BC144239 AAI44240 BM685020 CR936794 KJ534902 AHW56542 KJ534903 AHW56543 M23102 AAA36770 NM_001007792 NP_001007793 NM_001012331 NP_001012331 NM_002529 NP_002520
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15488758}; Single-pass type I membrane protein {ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}.
Top Pathways	Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active TrkA protein fragment - ab60887 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells

Human TrkA (phospho Y490) peptide - ab99483 from Abcam Category Peptide

TrkA protein (Fc Chimera) - ab83562 from Abcam Category Protein Source HEK 293 cells Species Human

TrkA peptide - ab116686 from Abcam Category Peptide

NTRK1 / TrkA Antibody Blocking Peptide - LS-E7328 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NTRK1 / TrkA Antibody Blocking Peptide - LS-E9190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NTRK1 / TrkA Antibody Blocking Peptide - LS-E9191 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TrkA Protein - P3887 from Novus Biologicals Category Protein Prices $1,369.00 Sizes 5 µg Source Insect Species Human

TrkA Recombinant Protein - P4785 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

TrkA Peptide - P2728 from Novus Biologicals Category Peptide Species Human

TrkA Peptide - P2727 from Novus Biologicals Category Peptide Species Human

TrkA Peptide - P1436 from Novus Biologicals Category Peptide Species Human

TrkA Peptide - P1435 from Novus Biologicals Category Peptide Species Human

Phospho-TrkAY791-Antibody-Blocking-peptide - BP3282a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-TrkAY676-Antibody-Blocking-peptide - BP3281a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

TrkA-pY791-Antibody-Blocking-Peptide - BP7686e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRKA-Antibody-Center-Blocking-Peptide - BP7686c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRKA-Antibody-C-term-L784-Blocking-Peptide - BP7686b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRKA-Antibody-C-term-Blocking-Peptide - BP7686a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TrkA Fc Chimera, CF - 175-TK-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Canine TrkA protein - orb139812 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Canine TrkA protein (His Tag) - orb139813 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

TrK A peptide - orb73301 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

TrkA Blocking Peptide - 33R-10666 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TrkA - P3887 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

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