SIGLEC1

Gene Symbol SIGLEC1
Entrez Gene 6614
Alt Symbol CD169, SIGLEC-1, SN, dJ1009E24.1
Species Human
Gene Type protein-coding
Description sialic acid binding Ig-like lectin 1, sialoadhesin
Other Description sialic acid-binding Ig-like lectin 1|sialic acid-binding immunoglobulin-like lectin 1|sialoadhesin
Swissprots Q9H1H7 Q9H7L7 Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6
Accessions EAX10517 EAX10518 Q9BZZ2 AF230073 AAK00757 AK024459 BAB15749 AK024462 BAB15752 AK024479 BAB15769 AK057560 BAB71527 AK122586 BAC56927 AL833688 AY927519 BC141884 AAI41885 CD365566 XM_006723610 XP_006723673 XM_011529324 XP_011527626 XM_011529325 XP_011527627 XM_011529326 XP_011527628 XM_011529327 XP_011527629 XM_011529328 XP_011527630 XM_011529329 XP_011527631 XM_011529330 XP_011527632 XM_011529331 XP_011527633 XM_011529332 XP_011527634 XM_011529333 XP_011527635 NM_023068 NP_075556
Function Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Top Pathways Cell adhesion molecules (CAMs)

Siglec-1 (B-1) - sc-398109 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Siglec-1 (B-1): sc-398109. Western blot analysis of Siglec-1 expression in Jurkat whole cell lysate.

Siglec-1 (HSn 7D2) - sc-53442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Siglec-1 (C-20) - sc-18655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Siglec-1 (H-56) - sc-367467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Siglec-1 (N-20) - sc-23594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Siglec-7 (A-7) - sc-398919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Siglec-7 (A-7): sc-398919. Western blot analysis of Siglec-7 expression in non-transfected: sc-117752 (A) and human Siglec-7 transfected: sc-114791 (B) 293T whole cell lysates.

Anti-Sialoadhesin antibody [7-239] (FITC) - ab64641 from Abcam

Prices $185.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-Sialoadhesin antibody [7-239], prediluted (Phycoerythrin) - ab200579 from Abcam

Prices $359.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-Sialoadhesin antibody [7239] - ab199401 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7239

Anti-Sialoadhesin antibody [HSn 7D2] - ab18619 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HSn 7D2
ab18619 staining human peripheral blood mononuclear cells by flow cytometry. The cells were prepared in FACS buffer (PBS, 0.5% FCS, 0.5M EDTA) and fixed in PFA without undergoing permeabilization. Cells were gated on lymphocyte and monocyte populations and incubated with primary antibody (1/25) for 20 minutes at 4°C. The secondary antibody used was Phycoerythrin-conjugated rat polyclonal to mouse Ig, diluted 1/100. The PBMC cells were almost exclusively CD14+ monocytic cells.See Abreview

Anti-Sialoadhesin antibody [SP216] - ab183356 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP216
Immunohistochemical analysis of formalin fixed, paraffin embedded Human bone marrow tissue sections labeling Sialoadhesin using ab183356 at a 1/100 dilution.

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C45080 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C45081 from LifeSpan Bioscience

Prices $365.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone HSn 7D2) - LS-C49351 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 7-239, Low Endotoxin) - LS-C58088 from LifeSpan Bioscience

Prices $445.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 7-239, FITC) - LS-C58089 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 7-239) - LS-C58091 from LifeSpan Bioscience

Prices $270.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 7-239, RPE) - LS-C58092 from LifeSpan Bioscience

Prices $345.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 7-239

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (PE) - LS-C75830 from LifeSpan Bioscience

Prices $455.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C124537 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone HSN1 7D2) - LS-C91383 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C124536 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C124538 from LifeSpan Bioscience

Prices $485.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody - LS-C124540 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µg
Host Rat
Clonality Monoclonal

Anti-SIGLEC1 / CD169 / Sialoadhesin Antibody (clone 7-239) - LS-C124542 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 7-239
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