SIGLEC1

Gene Symbol	SIGLEC1
Entrez Gene	6614
Alt Symbol	CD169, SIGLEC-1, SN, dJ1009E24.1
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 1, sialoadhesin
Other Description	sialic acid-binding Ig-like lectin 1|sialic acid-binding immunoglobulin-like lectin 1|sialoadhesin
Swissprots	Q9H1H7 Q9H7L7 Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6
Accessions	EAX10517 EAX10518 Q9BZZ2 AF230073 AAK00757 AK024459 BAB15749 AK024462 BAB15752 AK024479 BAB15769 AK057560 BAB71527 AK122586 BAC56927 AL833688 AY927519 BC141884 AAI41885 CD365566 XM_006723610 XP_006723673 XM_011529324 XP_011527626 XM_011529325 XP_011527627 XM_011529326 XP_011527628 XM_011529327 XP_011527629 XM_011529328 XP_011527630 XM_011529329 XP_011527631 XM_011529330 XP_011527632 XM_011529331 XP_011527633 XM_011529332 XP_011527634 XM_011529333 XP_011527635 NM_023068 NP_075556
Function	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse Siglec-1 Fc Chimera, CF - 5610-SL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Siglec-1, CF - 5197-SL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser20-Gln1641, with a C-terminal 6-His tag

Sialoadhesin peptide - orb72468 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Human SIGLEC1 Protein - abx069060 from Abbexa Category Protein Source E.coli Species Human

Human SIGLEC1 Protein - abx069061 from Abbexa Category Protein Source E.coli Species Human

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Human - 20-7345 from ARP American Research Products Category Protein Prices $409.00 Sizes 50 µg Source E.coli Species Human

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Human - 20-7346 from ARP American Research Products Category Protein Prices $409.00 Sizes 50 µg Source E.coli Species Human

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) - RPA966Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) - RPA966Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Secretogranin II (SCG2) - RPF859Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) - RPA966Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) - RPA966Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Sialoadhesin(SIGLEC1) ,partial - CSB-YP887180HU CSB-EP887180HU CSB-BP887180HU CSB-MP887180HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Siglec-1 Protein, CF - 5197-SL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ser20-Gln1641, with a C-terminal 6-His tag Species Human

Recombinant Mouse Siglec-1 Fc Chimera Protein, CF - 5610-SL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Mouse Siglec-1 (Thr20 - Arg1639) Accession # CAM18034 IEGRMDP Mouse IgG 2a (Glu98 - Lys330) N-terminus C-terminus Species Mouse

CD169 / SIGLEC1 - TP324969 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SIGLECL1 Recombinant Protein Antigen - NBP2-14794PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

SIGLEC1-Antibody-C-term-Blocking-Peptide - BP1621b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIGLEC1-Antibody-N-term-Blocking-Peptide - BP1621a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIGLEC1 Peptide, Human - M34GP14237H from Creative Peptides Category Peptide Source Synthetic. Species Human

Siglec-1/CD169 Recombinant Protein Antigen - NBP2-30903PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SIGLEC1 Recombinant Protein (OPCD06971) - OPCD06971 from Aviva Systems Biology Category Protein Source E.coli Species Human

SIGLEC1 Recombinant Protein (OPCD06972) - OPCD06972 from Aviva Systems Biology Category Protein Source E.coli Species Human

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Recombinant Protein - MBS2009114 from MyBioSource Category Protein Prices $160.00, $310.00, $480.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Recombinant Protein - MBS2009590 from MyBioSource Category Protein Prices $160.00, $310.00, $480.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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