| Gene Symbol | SIGLEC1 |
|---|---|
| Entrez Gene | 6614 |
| Alt Symbol | CD169, SIGLEC-1, SN, dJ1009E24.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sialic acid binding Ig-like lectin 1, sialoadhesin |
| Other Description | sialic acid-binding Ig-like lectin 1|sialic acid-binding immunoglobulin-like lectin 1|sialoadhesin |
| Swissprots | Q9H1H7 Q9H7L7 Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6 |
| Accessions | EAX10517 EAX10518 Q9BZZ2 AF230073 AAK00757 AK024459 BAB15749 AK024462 BAB15752 AK024479 BAB15769 AK057560 BAB71527 AK122586 BAC56927 AL833688 AY927519 BC141884 AAI41885 CD365566 XM_006723610 XP_006723673 XM_011529324 XP_011527626 XM_011529325 XP_011527627 XM_011529326 XP_011527628 XM_011529327 XP_011527629 XM_011529328 XP_011527630 XM_011529329 XP_011527631 XM_011529330 XP_011527632 XM_011529331 XP_011527633 XM_011529332 XP_011527634 XM_011529333 XP_011527635 NM_023068 NP_075556 |
| Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. |
| Top Pathways | Cell adhesion molecules (CAMs) |
Siglec-1 CRISPR/Cas9 KO Plasmid (h) - sc-402497 from Santa Cruz Biotechnology
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Siglec-1 HDR Plasmid (h) - sc-402497-HDR from Santa Cruz Biotechnology
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Siglec-1 Double Nickase Plasmid (h) - sc-402497-NIC from Santa Cruz Biotechnology
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Siglec-1 Double Nickase Plasmid (h2) - sc-402497-NIC-2 from Santa Cruz Biotechnology
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Siglec-1 CRISPR Activation Plasmid (h) - sc-402497-ACT from Santa Cruz Biotechnology
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Siglec-1 CRISPR Activation Plasmid (h2) - sc-402497-ACT-2 from Santa Cruz Biotechnology
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Siglec-1 Lentiviral Activation Particles (h) - sc-402497-LAC from Santa Cruz Biotechnology
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Siglec-1 Lentiviral Activation Particles (h2) - sc-402497-LAC-2 from Santa Cruz Biotechnology
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Siglec-1 siRNA (h) - sc-72064 from Santa Cruz Biotechnology
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Siglec-1 shRNA Plasmid (h) - sc-72064-SH from Santa Cruz Biotechnology
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Siglec-1 shRNA (h) Lentiviral Particles - sc-72064-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU146181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19326 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19326 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09870 from Sigma-Aldrich
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SIGLEC1 siRNA (Human) - CRH4497 from Cohesion Biosciences
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SIGLEC1 - MBS8212699 from MyBioSource
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shRNA set against Human SIGLEC1 (NM_023068.3) - SHH407420 from Creative biogene
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Human Sialoadhesin siRNA - orb264999 from Biorbyt
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SIGLEC1 shRNA Plasmid (Human) - CHH4497 from Cohesion Biosciences
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SIGLEC1 miRNA 3'UTR clone - MiUTR1H-09392 from Creative biogene
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