SIGLEC1

Gene Symbol	SIGLEC1
Entrez Gene	6614
Alt Symbol	CD169, SIGLEC-1, SN, dJ1009E24.1
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 1, sialoadhesin
Other Description	sialic acid-binding Ig-like lectin 1|sialic acid-binding immunoglobulin-like lectin 1|sialoadhesin
Swissprots	Q9H1H7 Q9H7L7 Q9BZZ2 Q96DL4 Q9GZS5 Q9H1H6
Accessions	EAX10517 EAX10518 Q9BZZ2 AF230073 AAK00757 AK024459 BAB15749 AK024462 BAB15752 AK024479 BAB15769 AK057560 BAB71527 AK122586 BAC56927 AL833688 AY927519 BC141884 AAI41885 CD365566 XM_006723610 XP_006723673 XM_011529324 XP_011527626 XM_011529325 XP_011527627 XM_011529326 XP_011527628 XM_011529327 XP_011527629 XM_011529328 XP_011527630 XM_011529329 XP_011527631 XM_011529330 XP_011527632 XM_011529331 XP_011527633 XM_011529332 XP_011527634 XM_011529333 XP_011527635 NM_023068 NP_075556
Function	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIGLEC1 / CD169 / Sialoadhesin ELISA Kit (Sandwich ELISA) - LS-F2964 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Mouse SIGLEC1 / CD169 / Sialoadhesin ELISA Kit (Sandwich ELISA) - LS-F2965 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Human SIGLEC1 / CD169 / Sialoadhesin ELISA Kit (Sandwich ELISA) - LS-F6314 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 156-10000 pg/ml

Secretogranin II (SCG2), Human, ELISA Kit - SEF859Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.47ng/mL Range 1.25-80ng/mL

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Human, ELISA Kit - SEA966Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

Sialoadhesin (SIGLEC1), Human, ELISA Kit - CSB-EL021293HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Human, ELISA Kit - E-EL-H1317 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Rabbit, ELISA Kit - E-EL-RB0462 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Chicken, ELISA Kit - E-EL-Ch0454 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Porcine, ELISA Kit - E-EL-P0193 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Sheep, ELISA Kit - E-EL-S0981 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Guinea Pig, ELISA Kit - E-EL-GP1108 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 1, SIGLEC1, Monkey, ELISA Kit - E-EL-MK0760 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS065288 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS066569 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS082456 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS049945 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS103719 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS096821 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS083510 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS092474 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS052549 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS098660 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS098153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 1, ELISA Kit - MBS075626 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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