TP53

Gene Symbol	TP53
Entrez Gene	7157
Alt Symbol	BCC7, LFS1, P53, TRP53
Species	Human
Gene Type	protein-coding
Description	tumor protein p53
Other Description	antigen NY-CO-13\|cellular tumor antigen p53\|mutant tumor protein 53\|p53 tumor suppressor\|phosphoprotein p53\|transformation-related protein 53\|tumor protein 53
Swissprots	Q3LRW4 Q99659 Q16809 Q8J016 Q9HAQ8 Q9BTM4 Q9UBI2 Q86UG1 Q3LRW2 Q2XN98 Q9UQ61 Q15086 Q16808 Q16811 Q9NPJ2 Q9NP68 Q15087 P04637 Q16535 Q3LRW1 Q15088 Q3LRW5 Q16810 Q16848 Q3LRW3 Q9NZD0 Q16807
Accessions	AAA59987 AAA59988 AAA83560 AAB39322 AAC12971 AAC27931 AAD28535 AAD28628 AAF36354 AAF36355 AAF36356 AAF36357 AAF36358 AAF36359 AAF36360 AAF36361 AAF36362 AAF36363 AAF36364 AAF36365 AAF36366 AAF36367 AAF36368 AAF36369 AAF36370 AAF36371 AAF36372 AAF36373 AAF36374 AAF36375 AAF36376 AAF36377 AAF36378 AAF36379 AAF36380 AAF36381 AAF36382 AAF63442 AAF63443 AAK76358 AAK76359 AAP30003 AAQ90158 AAR13239 AAV80424 AAZ05887 ABF51616 ABF51617 ABF51618 ABF51619 ABF61799 ABG67755 ABM69022 ABM69023 ABM69024 ABM69025 ABM69026 ABM69027 ABO28385 ABO28386 ABO28387 ABO28388 ABO28389 ABO28390 ABO28391 ABO28392 ABO28393 ABO28394 ABO28395 ABO28396 ABO28397 ABO28398 ABO28399 ABO28400 ABO28401 ABO28402 ABO28403 ABO28404 ABO28405 ABO28406 ABO28407 ABO28408 ABO28409 ABO28410 ABO28411 ABO28412 ABO28413 ABO28414 ABO28415 ABO28416 ABO28417 ABO28418 ABO28419 ABO28420 ABO28421 ABO28422 ABO28423 ABO28424 ABO28425 ABO28426 ABO28427 ABO28428 ABO28429 ABO28430 ABO28431 ABO28432 ABO28433 ABO28434 ABO28435 ABO28436 ABO28437 ABO28438 ABO28439 ABO30992 ABO30993 ABO30994 ABO30995 ABO30996 ABO30997 ABO30998 ABO30999 ABO31000 ABO31001 ABO31002 ABO31003 ABO31004 ABO31005 ABO31006 ABO31007 ABO31008 ABO31009 ABO31010 ABO31011 ABO31012 ABV21350 ABV21351 ABV21352 ACA63978 ACA79923 ACD01218 ACD01219 ACD01220 ACD01221 ACF94998 ACF94999 ACF95000 ACF95001 ADE43214 ADE43215 ADE43216 ADE43217 ADE43218 ADN42962 AEQ16481 AEQ16482 AEQ16483 AEQ16484 AEQ16485 AEQ16486 AGA62529 AGA62530 AGA62531 AGA62532 AGA62533 AGA62534 AGA62535 AGA62536 AGA62537 AGA62538 AGA62539 AGA62540 AGA62541 AGA62542 AGA62543 AGA62544 AGA62545 AGA62546 AGA62547 AGA62548 AGA62549 AGA62550 AGA62551 AGA62552 AGA62553 AGA62554 AGA62555 AGA62556 AGA62557 AGA62558 AGA62559 AGA62560 AGA62561 AGA62562 AGA62563 AGA62564 AGA62565 AGA62566 AGA62567 AGA62568 AGA62569 AGA62570 AGA62571 AGA62572 AGA62573 AGA62574 AGA62575 AGA62576 AGA62577 AGA62578 AGA62579 AGA62580 AGA62581 AGA62582 AGA62583 AGA62584 AGA62585 AGA62586 AGA62587 AGA62588 AGA62589 AGA62590 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AGA63368 AGA63369 AGA63370 AGA63371 AGA63372 AGA63373 AGA63374 AGA63375 AGA63376 AGA63377 AGA63378 AGA63379 AGA63380 AGA63381 AGA63382 AGA63383 AGA63384 AGA63385 AGA63386 AGA63387 AGA63388 AGA63389 AGA63390 AGA63391 AGA63392 AGA63393 AGA63394 AGA63395 AGA63396 AGA63397 AGA63398 AGA63399 AGA63400 AGA63401 AGA63402 AGA63403 AGA63404 AGA63405 AGA63406 AGA63407 AGA63408 AGA63409 AGA63410 AGA63411 AGA63412 AGA63413 AGA63414 AGA63415 AGA63416 AGA63417 AGA63418 AGA63419 AGA63420 AGA63421 AGA63422 AGA63423 AGA63424 AGA63425 AGA63426 AGA63427 AGA63428 AGA63429 AGA63430 AGA63431 AGA63432 AGA63433 AGA63434 AGA63435 AGA63436 AGA63437 AGA63438 AHA34178 AHA34179 AHA34180 AHA34181 AHA34182 AHA34183 AHZ21039 AHZ21040 AHZ21041 AIW39812 AIW39813 BAD11806 BAJ52715 BAL63031 BAL63213 BAL63820 CAA38095 CDM63359 EAW90140 EAW90141 EAW90142 EAW90143 EAW90144 EAW90145 P04637 AB082923 BAC16799 AF052180 AF307851 AAG28785 AK223026 BAD96746 AK225838 AK297462 BAG59884 AK297927 BAG60244 AK303277 BAG64357 AK312568 BAG35463 AM076970 CAJ28922 AM076971 CAJ28924 AM076972 CAJ28923 AU131823 AY429684 AAR10356 AY627884 AAT40418 BC003596 AAH03596 BT019622 AAV38428 DA308036 DA453049 DA932053 DC347346 DQ186648 ABA29753 DQ186649 ABA29754 DQ186650 ABA29755 DQ186651 ABA29756 DQ186652 ABA29757 DQ191317 ABB80262 DQ263704 ABB72446 DQ286964 ABB80266 DQ401704 ABD62752 DQ485152 ABF61800 DQ648883 DQ648884 ABG49480 DQ648885 ABG49481 DQ648886 DQ648887 ABG49482 DQ892492 ABM83418 DQ895704 ABM86630 EF101867 ABL09846 EF101868 ABL09847 EF101869 ABL09848 FJ207420 ACI25593 HG975427 JN601513 AEY81366 JN601514 AEY81367 JN601515 AEY81368 JN601516 AEY81369 JN900492 AEX20383 JQ026207 JQ026208 JQ026209 JQ026210 JQ694049 AFN61604 JQ694050 AFN61605 JQ694051 AFN61606 KC820708 AGR27803 KC820709 AGR27804 KC820710 AGR27805 KC820711 AGR27806 KC820712 AGR27807 KC820713 AGR27808 KC820714 AGR27809 KC820715 AGR27810 KC820716 AGR27811 KC820717 AGR27812 KC820718 AGR27813 KC820719 AGR27814 KC820720 AGR27815 KC820721 AGR27816 KC820722 AGR27817 KC820723 AGR27818 KC820724 AGR27819 KC820725 AGR27820 KC820726 AGR27821 KC820727 AGR27822 KC820728 AGR27823 KC820729 AGR27824 KC820730 AGR27825 KC820731 AGR27826 KC820732 AGR27827 KC820733 AGR27828 KC820734 AGR27829 KC820735 AGR27830 KC820736 AGR27831 KC820737 AGR27832 KC820738 AGR27833 KC820739 AGR27834 KC820740 AGR27835 KC820741 AGR27836 KC820742 AGR27837 KC820743 AGR27838 KC820744 AGR27839 KC820745 AGR27840 KC820746 AGR27841 KC820747 AGR27842 KC820748 AGR27843 KC820749 AGR27844 KC820750 AGR27845 KC820751 AGR27846 KC820752 AGR27847 KC820753 AGR27848 KC820754 AGR27849 KC820755 AGR27850 KC820756 AGR27851 KC820757 AGR27852 KC820758 AGR27853 KC820759 AGR27854 KC820760 AGR27855 KC820761 AGR27856 KC820762 AGR27857 KC820763 AGR27858 KC820764 AGR27859 KC820765 AGR27860 KC820766 AGR27861 KC820767 AGR27862 KC820768 AGR27863 KC820769 AGR27864 KC820770 AGR27865 KC820771 AGR27866 KC820772 AGR27867 KC820773 AGR27868 KC820774 AGR27869 KC820775 AGR27870 KC820776 AGR27871 KC820777 AGR27872 KC820778 AGR27873 KC820779 AGR27874 KC820780 AGR27875 KC820781 AGR27876 KC820782 AGR27877 KC820783 AGR27878 KC820784 AGR27879 KC820785 AGR27880 KC820786 AGR27881 M14694 AAA61211 M14695 AAA61212 S66666 AAB28601 X01405 CAA25652 X02469 CAA26306 X60010 CAA42625 X60011 CAA42626 X60012 CAA42627 X60013 CAA42628 X60014 CAA42629 X60015 CAA42630 X60016 CAA42631 X60017 CAA42632 X60018 CAA42633 X60019 CAA42634 X60020 CAA42635 NM_000546 NP_000537 NM_001126112 NP_001119584 NM_001126113 NP_001119585 NM_001126114 NP_001119586 NM_001126115 NP_001119587 NM_001126116 NP_001119588 NM_001126117 NP_001119589 NM_001126118 NP_001119590 NM_001276695 NP_001263624 NM_001276696 NP_001263625 NM_001276697 NP_001263626 NM_001276698 NP_001263627 NM_001276699 NP_001263628 NM_001276760 NP_001263689 NM_001276761 NP_001263690
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK
Subcellular Location	Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.
Tissue Specificity	Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine. {ECO:0000269\|PubMed:16131611}.
Top Pathways	Measles, Epstein-Barr virus infection, Sphingolipid signaling pathway, Apoptosis, Central carbon metabolism in cancer

Phospho-p53 (Ser15) (16G8) Mouse mAb (Biotinylated) - 4030 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (10 western blots)
Host	Mouse
Clonality	Monoclonal
Clone	16G8

Western blot analysis of extracts from HT-29 cells, untreated (-) or UV-treated (+), using Phospho-p53 (Ser15) (16G8) Mouse mAb (Biotinylated) and detected with Strepavidin-HRP #3999.

Phospho-p53 (Ser15) (16G8) Mouse mAb (PE Conjugate) - 8514 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Mouse
Clonality	Monoclonal
Clone	16G8

Flow cytometric analysis of HT-29 cells, untreated (blue) or UV-treated (green), using Phospho-p53 (Ser15) (16G8) Mouse mAb (PE Conjugate).

Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 9235 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Mouse
Clonality	Monoclonal
Clone	16G8

Flow cytometric analysis of HT-29 cells, untreated (blue) or UV-treated (green), using Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor ® 488 Conjugate).

Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 8695 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Mouse
Clonality	Monoclonal
Clone	16G8

Flow cytometric analysis of HT-29 cells, untreated (blue) or UV-treated (green), using Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor ® 647 Conjugate).

p53 (1C12) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 2015 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Mouse
Clonality	Monoclonal
Clone	1C12

Flow cytometric analysis of K562 (blue) and HT-29 cells (green) using p53 (1C12) Mouse mAb (Alexa Fluor® 488 Conjugate).

p53 (7F5) Rabbit mAb (Biotinylated) - 4667 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	7F5

Western blot analysis of extracts from 293 and COS cells using p53 (7F5) Rabbit mAb (Biotinylated) and developed with Streptavidin-HRP #3999.

p53 (1C12) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 2533 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Mouse
Clonality	Monoclonal
Clone	1C12

Flow cytometric analysis of K562 (blue) and HT-29 (green) cells using p53 (1C12) Mouse mAb (Alexa Fluor ® 647 Conjugate).

p53 (7F5) Rabbit mAb (PE Conjugate) - 8712 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Rabbit
Clonality	Monoclonal
Clone	7F5

Flow cytometric analysis of K-562 (blue) or HT-29 (green) cells using p53 (7F5) Rabbit mAb (PE Conjugate).

p53 (7F5) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 5429 from Cell Signaling Technology

Prices	$299.00
Sizes	100 µl (50 tests)
Host	Rabbit
Clonality	Monoclonal
Clone	7F5

Confocal immunofluorescent analysis of HT-29 cells (positive) (left) and THP-1 cells (negative) (right) using p53 (7F5) Rabbit mAb (Alexa Fluor® 488 Conjugate) (green). Actin filaments have been labeled with DY-554 phalloidin (red).

Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor ® 555 Conjugate) - 9481 from Cell Signaling Technology

Host	Mouse
Clonality	Monoclonal
Clone	16G8

p53 (7F5) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 5395 from Cell Signaling Technology

Host	Rabbit
Clonality	Monoclonal
Clone	7F5

Phospho-p53 (Ser15) Antibody - 9284 from Cell Signaling Technology

Prices	$109.00, $287.00, $678.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from MvILu cells treated with UV or hydroxyurea (20 mM) for the indicated times, using Phospho-p53 (Ser15) Antibody.

Phospho-p53 (Ser6) Antibody - 9285 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from COS cells treated with UV or MMS for the indicated times, using Phospho-p53 (Ser6) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser15) (16G8) Mouse mAb - 9286 from Cell Signaling Technology

Prices	$109.00, $287.00, $678.00
Sizes	20 µl (2 western blots), 100 µl (20 western blots), 300 µl (60 western blots)
Host	Mouse
Clonality	Monoclonal
Clone	16G8

Western blot analysis of extracts from HT29 cells, untreated or UV-treated (100 mJ/cm2, 1 hr), using Phospho-p53 (Ser15) (16G8) Mouse mAb (upper) or p53 (DO-7) Mouse mAb #48818 (lower).

Phospho-p53 (Ser20) Antibody - 9287 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from COS cells treated with UV or MMS for the indicated times, using Phospho-p53 (Ser20) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser315) Antibody - 2528 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from MCF-7 cells, untreated or treated with nocodazole (50 ng/ml, 48h) or nocodazole plus Lambda Phosphatase NEB#P0753 (10,000 Units/ml, 1h), using Phospho-p53 (Ser315) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser9) Antibody - 9288 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from COS cells treated with UV or MMS for the indicated times, using Phospho-p53 (Ser9) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser33) Antibody - 2526 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HT29 cells treated with nocodazole (50 ng/ml, 24h), calyculin A #9902 (100 nM, 10 min), or lambda Phosphatase NEB#P0753 (10,000 units/ml, 1 h), using Phospho-p53 (Ser33) Antibody (upper) or p53 (1C12) Mouse mAb #2524 (lower).

Phospho-p53 (Thr81) Antibody - 2676 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HT29 cells, untreated, nocodazole-treated (50 ng/ml, 24h) or UV-treated (50mJ/cm2, 1hr), using Phospho-p53 (Thr81) Antibody (upper), p53 (1C12) Mouse mAb #2524 (middle), or Phospho-SAPK/JNK(T183/Y185) (98F2) Rabbit mAb #4671 (lower).

Phospho-p53 (Thr18) Antibody - 2529 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from MCF-7 cells treated with doxorubicin (0.5 uM, 24 h) or doxorubicin plus lambda Phosphatase NEB#P0753 (10,000 Units/ml, 1h), using Phospho-p53 (Thr18) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser37) Antibody - 9289 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from COS cells treated with UV or MMS, and 293 cells treated with UV, using Phospho-p53 (Ser37) Antibody (upper) or p53 Antibody #9282 (lower).

Phospho-p53 (Ser46) Antibody - 2521 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from MCF-7 cells treated with etoposide for the indicated times, using Phospho-p53 (Ser46) Antibody.

Phospho-p53 (Ser392) Antibody - 9281 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of increasing amounts of a p53 fusion protein, untreated or phosphorylated by CKII, using Phospho-p53 (Ser392) Antibody (upper) or p53 Antibody #9282 (lower).

Acetyl-p53 (Lys379) Antibody - 2570 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from NIH/3T3 (left) and MCF-7 (right) cells, untreated, doxorubicin-treated (0.5 μM, 24 hours) or doxorubicin and trichostatin A-treated (TSA, #9950, 400 nM, 24 hours), using Acetyl-p53 (Lys379) Antibody.

Acetyl-p53 (Lys382) Antibody - 2525 from Cell Signaling Technology

Prices	$287.00, $678.00
Sizes	100 µl (10 western blots), 300 µl (30 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa cells, untreated or treated with both trichostatin A #9950 (400 nM for 24 hours), and doxorubicin (0.5 µM for 24 hours) using Acetyl-p53 (Lys382) Antibody alone (A), antibody preincubated with a non-acetylated Lys382 peptide (B), or antibody preincubated with an acetylated Lys382 peptide (C).

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