| Gene Symbol |
ERCC6L
|
| Entrez Gene |
54821
|
| Alt Symbol |
PICH, RAD26L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 6-like
|
| Other Description |
ATP-dependent helicase ERCC6-like|DNA excision repair protein ERCC-6-like|Plk1-interacting checkpoint helicase|SNF2/RAD54 family protein|excision repair cross-complementing rodent repair deficiency complementation group 6 - like|excision repair cross-complementing rodent repair deficiency, complementation group 6-like|excision repair protein ERCC6-like|tumor antigen BJ-HCC-15
|
| Swissprots |
Q8NCI1 Q96H93 Q9NXQ8 Q2NKX8
|
| Accessions |
CCQ89140 EAW71813 EAW71814 Q2NKX8 AK000112 BAA90952 AK056494 AK074719 BAC11160 AW015865 AY121802 AAM82750 BC008808 AAH08808 BC111486 AAI11487 BM454829 BU431499 EU069463 ABU25227 NM_001009954 NM_017669 NP_060139
|
| Function |
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. {ECO:0000269|PubMed:17218258}.
|
| Subcellular Location |
Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
|