ERCC6L

Gene Symbol ERCC6L
Entrez Gene 54821
Alt Symbol PICH, RAD26L
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 6-like
Other Description ATP-dependent helicase ERCC6-like|DNA excision repair protein ERCC-6-like|Plk1-interacting checkpoint helicase|SNF2/RAD54 family protein|excision repair cross-complementing rodent repair deficiency complementation group 6 - like|excision repair cross-complementing rodent repair deficiency, complementation group 6-like|excision repair protein ERCC6-like|tumor antigen BJ-HCC-15
Swissprots Q8NCI1 Q96H93 Q9NXQ8 Q2NKX8
Accessions CCQ89140 EAW71813 EAW71814 Q2NKX8 AK000112 BAA90952 AK056494 AK074719 BAC11160 AW015865 AY121802 AAM82750 BC008808 AAH08808 BC111486 AAI11487 BM454829 BU431499 EU069463 ABU25227 NM_001009954 NM_017669 NP_060139
Function DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. {ECO:0000269|PubMed:17218258}.
Subcellular Location Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.

Human ERCC6L full length protein - ab162850 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162850 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ERCC6L / FLJ20105 Antibody Blocking Peptide - LS-E20775 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human ERCC6L Protein - H00054821-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

ERCC6L Blocking Peptide - 33R-3202 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

ERCC6L - H00054821-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

ERCC6L - H00054821-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

ERCC6L fusion protein - ag8223 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

ERCC6L fusion protein - ag8238 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human DNA excision repair protein ERCC-6-like(ERCC6L) ,partial - CSB-YP650698HU CSB-EP650698HU CSB-BP650698HU CSB-MP650698HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

ERCC6L Recombinant Protein Antigen - NBP2-13969PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ERCC6L Peptide, Human - M34GP05039H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

DNA excision repair protein ERCC-6-like (ERCC6L), partial, Recombinant Protein - MBS1425339 from MyBioSource

Category Protein
Prices $935.00, $935.00, $1,160.00, $1,160.00, $1,340.00, $1,340.00, $1,800.00, $1,800.00, $1,835.00, $2,635.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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