ERCC6L

Gene Symbol	ERCC6L
Entrez Gene	54821
Alt Symbol	PICH, RAD26L
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 6-like
Other Description	ATP-dependent helicase ERCC6-like|DNA excision repair protein ERCC-6-like|Plk1-interacting checkpoint helicase|SNF2/RAD54 family protein|excision repair cross-complementing rodent repair deficiency complementation group 6 - like|excision repair cross-complementing rodent repair deficiency, complementation group 6-like|excision repair protein ERCC6-like|tumor antigen BJ-HCC-15
Swissprots	Q8NCI1 Q96H93 Q9NXQ8 Q2NKX8
Accessions	CCQ89140 EAW71813 EAW71814 Q2NKX8 AK000112 BAA90952 AK056494 AK074719 BAC11160 AW015865 AY121802 AAM82750 BC008808 AAH08808 BC111486 AAI11487 BM454829 BU431499 EU069463 ABU25227 NM_001009954 NM_017669 NP_060139
Function	DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. {ECO:0000269|PubMed:17218258}.
Subcellular Location	Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PICH (D4G8) Rabbit mAb - 8886 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D4G8

PICH (G-14) - sc-138047 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PICH (T-13) - sc-138048 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ERCC6L antibody - ab197925 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ERCC6L antibody - ab88560 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-ERCC6L antibody - ab192588 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ERCC6L antibody - ab57434 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ERCC6L / FLJ20105 Antibody (clone 3F12-2B10) - LS-C307421 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F12-2B10

Anti-ERCC6L / FLJ20105 Antibody - LS-C310272 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody - LS-C310268 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody - LS-C307422 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody - LS-C335221 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody - LS-C341938 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody (aa35-84) - LS-C111956 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ERCC6L / FLJ20105 Antibody - LS-C334515 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ERCC6L Antibody - H00054821-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RAD26L Antibody - NBP1-81944 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ERCC6L Antibody - NBP2-13969 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ERCC6L Antibody - NBP1-56332 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

ERCC6L Antibody - H00054821-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

ERCC6L Antibody (3F12-2B10) - H00054821-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F12-2B10

ERCC6L Polyclonal Antibody - bs-6380R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ERCC6L antibody produced in rabbit - SAB1411013 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Monoclonal Anti-FLJ20105 antibody produced in mouse - WH0054821M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F12-2B10

Anti-ERCC6L, (N-terminal) antibody produced in rabbit - SAB2106025 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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