ERCC6L

Gene Symbol ERCC6L
Entrez Gene 54821
Alt Symbol PICH, RAD26L
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 6-like
Other Description ATP-dependent helicase ERCC6-like|DNA excision repair protein ERCC-6-like|Plk1-interacting checkpoint helicase|SNF2/RAD54 family protein|excision repair cross-complementing rodent repair deficiency complementation group 6 - like|excision repair cross-complementing rodent repair deficiency, complementation group 6-like|excision repair protein ERCC6-like|tumor antigen BJ-HCC-15
Swissprots Q8NCI1 Q96H93 Q9NXQ8 Q2NKX8
Accessions CCQ89140 EAW71813 EAW71814 Q2NKX8 AK000112 BAA90952 AK056494 AK074719 BAC11160 AW015865 AY121802 AAM82750 BC008808 AAH08808 BC111486 AAI11487 BM454829 BU431499 EU069463 ABU25227 NM_001009954 NM_017669 NP_060139
Function DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. {ECO:0000269|PubMed:17218258}.
Subcellular Location Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.

ERCC6L - MBS1271972 from MyBioSource

Species Human
Accession BC008808

Human ERCC6L cDNA clone(NM_017669.2) - CDFG000896 from Creative Biomart

Species Human
Accession NM_017669.2

Human ERCC6L ORF Clone(NM_017669.2) - CDCL162563 from Creative Biomart

Species Human
Accession NM_017669.2

Human ERCC6L ORF Clone(NM_017669.2) - CDCL162564 from Creative Biomart

Species Human
Accession NM_017669.2

Human ERCC6L ORF Clone(NM_017669.2) - CDCR302164 from Creative Biomart

Species Human
Accession NM_017669.2

Human ERCC6L ORF Clone(NM_017669.2) - CDCR302165 from Creative Biomart

Species Human
Accession NM_017669.2

Human ERCC6L ORF Clone(NM_017669.2) - CDCR302164 from Creative biogene

Species Human

Human ERCC6L ORF Clone (BC008808) - CDCS414460 from Creative biogene

Species Human
Accession Q2NKX8

Human ERCC6L cDNA Clone(NM_017669.2) - CDFG000896 from Creative biogene

Species Human
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