| Gene Symbol |
WBP11
|
| Entrez Gene |
51729
|
| Alt Symbol |
NPWBP, PPP1R165, SIPP1, WBP-11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WW domain binding protein 11
|
| Other Description |
Npw38-binding protein NpwBP|SH3 domain-binding protein SNP70|WW domain-binding protein 11|protein phosphatase 1, regulatory subunit 165|splicing factor that interacts with PQBP-1 and PP1|splicing factor, PQBP1 and PP1 interacting
|
| Swissprots |
Q96AY8 Q9Y2W2
|
| Accessions |
EAW96328 EAW96329 Q9Y2W2 AB029309 BAA88410 AF118023 AAD30425 AK297410 BAG59845 AK302244 BAG63596 BC001621 AAH01621 BC016441 AAH16441 BC023532 AAH23532 BX647347 DQ892540 ABM83466 DQ895751 ABM86677 NM_016312 NP_057396
|
| Function |
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung. {ECO:0000269|PubMed:11375989}.
|
| Top Pathways |
Spliceosome
|