Gene Symbol | NDNL2 |
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Entrez Gene | 56160 |
Alt Symbol | HCA4, MAGEG1, MAGEL3, NSE3, NSMCE3 |
Species | Human |
Gene Type | protein-coding |
Description | necdin-like 2 |
Other Description | MAGE-G1 antigen|hepatocellular carcinoma-associated protein 4|hepatocellular carcinoma-associated protein HCA4|melanoma antigen, family G, 1|melanoma-associated antigen G1|necdin-like gene 2|necdin-like protein 2 |
Swissprots | Q9H214 Q8TEI6 Q96MG7 Q8IW16 |
Accessions | AAG38607 EAW51515 Q96MG7 AF490510 AAM08357 AK056957 BAB71325 AK074138 BAB84964 AU310582 BC035458 BC041166 AAH41166 BC053999 AAH53999 NM_138704 NP_619649 |
Function | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. {ECO:0000269|PubMed:20864041}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11782285}. |
MAGE-G1 (N-15) - sc-160508 from Santa Cruz Biotechnology
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Anti-NDNL2 antibody - ab198686 from Abcam
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Anti-NDNL2 Antibody (aa215-264) - LS-C116746 from LifeSpan Bioscience
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NDNL2 Antibody - NBP1-79687 from Novus Biologicals
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NDNL2 Antibody (4F7) - H00056160-M02-100ug from Novus Biologicals
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Anti-NDNL2 antibody produced in rabbit - SAB2106165 from Sigma-Aldrich
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Anti-NDNL2 antibody produced in rabbit - SAB4300836 from Sigma-Aldrich
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Monoclonal Anti-NDNL2 antibody produced in mouse - SAB1412854 from Sigma-Aldrich
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NDNL2 antibody - middle region (ARP57727_P050) - ARP57727_P050 from Aviva Systems Biology
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NDNL2 antibody - H00056160-M02 from Acris Antibodies
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NDNL2 Antibody - 37388 from Signalway Antibody
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NDNL2 Antibody - GWB-MU947B from Genway Biotech
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NDNL2 Polyclonal Antibody - ESAP13279 from Elabscience
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NDNL2 Polyclonal Antibody - ESAP16578 from Elabscience
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Anti-NDNL2 monoclonal antibody, clone 5G8 - DCABH-12529 from Creative Diagnostics
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NDNL2, Polyclonal Antibody - MBS2523992 from MyBioSource
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NDNL2, Polyclonal Antibody - MBS2521776 from MyBioSource
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NDNL2 antibody - 70R-9531 from Fitzgerald
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NDNL2, Polyclonal Antibody - MBS9413369 from MyBioSource
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NDNL2 antibody - TA344633 from Acris Antibodies
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anti-MAGE-G1 / Necdin-like 2 antibody, rabbit serum (MG1) - 74-114 from B-Bridge
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NDNL2 Antibody - CSB-PA289915 from Cusabio
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NDNL2 Antibody - CSB-PA977374 from Cusabio
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MAGEG1 antibody (FITC) - orb222178 from Biorbyt
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NDNL2 antibody - orb253734 from Biorbyt
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