NDNL2

Gene Symbol NDNL2
Entrez Gene 56160
Alt Symbol HCA4, MAGEG1, MAGEL3, NSE3, NSMCE3
Species Human
Gene Type protein-coding
Description necdin-like 2
Other Description MAGE-G1 antigen|hepatocellular carcinoma-associated protein 4|hepatocellular carcinoma-associated protein HCA4|melanoma antigen, family G, 1|melanoma-associated antigen G1|necdin-like gene 2|necdin-like protein 2
Swissprots Q9H214 Q8TEI6 Q96MG7 Q8IW16
Accessions AAG38607 EAW51515 Q96MG7 AF490510 AAM08357 AK056957 BAB71325 AK074138 BAB84964 AU310582 BC035458 BC041166 AAH41166 BC053999 AAH53999 NM_138704 NP_619649
Function Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. {ECO:0000269|PubMed:20864041}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:11782285}.

Human NDNL2 protein fragment - ab163353 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163353 on a 12.5% SDS-PAGE stained with Coomassie Blue.

NDNL2 Antibody Blocking Peptide - LS-E21085 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human NDNL2 Protein - H00056160-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

MAGG1-Antibody-C-term-Blocking-Peptide - BP9446b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

NDNL2 - H00056160-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

NDNL2 - H00056160-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Recombinant Human Melanoma-associated antigen G1(NDNL2) - CSB-YP856984HU CSB-EP856984HU CSB-BP856984HU CSB-MP856984HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

NDNL2 Peptide, Human - M34GP10216H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

NDNL2 fusion protein - Ag26663 from Proteintech Group

Category Protein
Source E. coli -derived, PGEX-4T
Species Human

Melanoma-associated antigen G1 (NDNL2), Recombinant Protein - MBS1371473 from MyBioSource

Category Protein
Prices $1,060.00, $1,060.00, $1,290.00, $1,290.00, $1,655.00, $1,655.00, $2,120.00, $2,120.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

NDNL2 fusion protein - Ag26673 from Proteintech Group

Category Protein
Source E. coli -derived, PET28a
Species Human
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