| Gene Symbol |
NDNL2
|
| Entrez Gene |
56160
|
| Alt Symbol |
HCA4, MAGEG1, MAGEL3, NSE3, NSMCE3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
necdin-like 2
|
| Other Description |
MAGE-G1 antigen|hepatocellular carcinoma-associated protein 4|hepatocellular carcinoma-associated protein HCA4|melanoma antigen, family G, 1|melanoma-associated antigen G1|necdin-like gene 2|necdin-like protein 2
|
| Swissprots |
Q9H214 Q8TEI6 Q96MG7 Q8IW16
|
| Accessions |
AAG38607 EAW51515 Q96MG7 AF490510 AAM08357 AK056957 BAB71325 AK074138 BAB84964 AU310582 BC035458 BC041166 AAH41166 BC053999 AAH53999 NM_138704 NP_619649
|
| Function |
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. {ECO:0000269|PubMed:20864041}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11782285}.
|