| Gene Symbol |
CYSLTR1
|
| Entrez Gene |
10800
|
| Alt Symbol |
CYSLT1, CYSLT1R, CYSLTR, HMTMF81
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cysteinyl leukotriene receptor 1
|
| Other Description |
G-protein coupled receptor HG55|LTD4 receptor|cysteinyl leukotriene D4 receptor
|
| Swissprots |
Q5JS94 Q8IV19 Q9Y271 D3DTE4 B2R954
|
| Accessions |
AAO92297 CAC38932 CCF76997 EAW98598 EAW98599 Q9Y271 AF119711 AAD42285 AF133266 AAD42778 AK023929 AK313643 BAG36401 BC035750 AAH35750 DQ131799 ABA01563 DQ131800 ABA01564 DQ131801 ABA01565 DQ131802 ABA01566 DQ131803 ABA01567 DQ890947 ABM81873 EU176542 ABW03343 NM_001282186 NP_001269115 NM_001282187 NP_001269116 NM_001282188 NP_001269117 NM_006639 NP_006630
|
| Function |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|