CYSLTR1

Gene Symbol CYSLTR1
Entrez Gene 10800
Alt Symbol CYSLT1, CYSLT1R, CYSLTR, HMTMF81
Species Human
Gene Type protein-coding
Description cysteinyl leukotriene receptor 1
Other Description G-protein coupled receptor HG55|LTD4 receptor|cysteinyl leukotriene D4 receptor
Swissprots Q5JS94 Q8IV19 Q9Y271 D3DTE4 B2R954
Accessions AAO92297 CAC38932 CCF76997 EAW98598 EAW98599 Q9Y271 AF119711 AAD42285 AF133266 AAD42778 AK023929 AK313643 BAG36401 BC035750 AAH35750 DQ131799 ABA01563 DQ131800 ABA01564 DQ131801 ABA01565 DQ131802 ABA01566 DQ131803 ABA01567 DQ890947 ABM81873 EU176542 ABW03343 NM_001282186 NP_001269115 NM_001282187 NP_001269116 NM_001282188 NP_001269117 NM_006639 NP_006630
Function Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Top Pathways Calcium signaling pathway, Neuroactive ligand-receptor interaction

CysLT 1 Receptor (C-16) - sc-31172 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CysLT<sub>1</sub> Receptor (C-16): sc-31172. Western blot analysis of CysLT<sub>1</sub> Receptor expression in HUV-EC-C whole cell lysate.

CysLT 1 Receptor (H-60) - sc-25448 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CysLT 1 Receptor (N-20) - sc-16946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CysLT 1 Receptor (T-16) - sc-31171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CysLT1 antibody - ab75157 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CysLT1 antibody (ab75157) at 1/500 dilutionLane 1 : Extracts from COS7 cellsLane 2 : Extracts from COS7 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CysLT1 antibody - ab93481 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CysLT1 antibody (ab93481) at 1/2000 dilutionLane 1 : Mouse spleen lysate at 49 µgLane 2 : Mouse spleen lysate at 49 µgLane 3 : Jurkat cell lysate at 54 µgLane 4 : Jurkat cell lysate at 54 µg

Anti-CysLT1 antibody - ab122959 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CysLT1 antibody (ab122959) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-CysLT1 antibody - ab95492 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-CysLT1 antibody - N-terminal - ab151484 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CysLT1 antibody - N-terminal (ab151484) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-CYSLTR1 / CYSLT1 Antibody (aa131-180) IHC-plus™ - LS-B9269 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CYSLTR1 / CYSLT1 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYSLTR1 / CYSLT1 Antibody (C-Terminus) IHC-plus™ - LS-A1320 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CYSLTR1 / CYSLT1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYSLTR1 / CYSLT1 Antibody (Extracellular Domain) IHC-plus™ - LS-A1317 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CYSLTR1 / CYSLT1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYSLTR1 / CYSLT1 Antibody - LS-C146665 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody - LS-C137435 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, AP) - LS-C213484 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa199-248) - LS-C146048 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYSLTR1 / CYSLT1 antibody LS-C146048 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-CYSLTR1 / CYSLT1 Antibody (Cys173) - LS-C177083 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CysLTR1 (C173) pAb in extracts from COLO205 cells.

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, APC) - LS-C213485 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (Lys172) - LS-C177152 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CysLTR1 (K172) pAb in extracts from COS-7 cells.

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, FITC) - LS-C213487 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, Biotin) - LS-C213486 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, Azide-free, HRP) - LS-C213488 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172, PE) - LS-C213490 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa124-173) - LS-C291847 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYSLTR1 / CYSLT1 Antibody (aa143-172) - LS-C320721 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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