| Gene Symbol |
LTN1
|
| Entrez Gene |
26046
|
| Alt Symbol |
C21orf10, C21orf98, RNF160, ZNF294
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
listerin E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin-protein ligase listerin|ring finger protein 160|zinc finger protein 294
|
| Swissprots |
A6NL41 O94822 Q9H8M4 Q05C47 A7E2D0 C9J7U3 Q9P0E9 Q9NUY5 B2RTS0 J3KPL4
|
| Accessions |
CAB90429 CAB90430 EAX09935 EAX09936 EAX09937 O94822 AB018257 BAA34434 AB621822 BAK64157 AF161350 AAF28910 AK001915 BAA91976 AK023499 BAB14589 BC007525 BC029371 AAH29371 BC031633 BC045726 BC140790 AAI40791 BC150284 AAI50285 BF059116 DB452437 XM_006723987 XP_006724050 XM_011529525 XP_011527827 NM_015565 NP_056380
|
| Function |
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). {ECO:0000250|UniProtKB:Q04781, ECO:0000269|PubMed:23685075, ECO:0000269|PubMed:25132172, ECO:0000269|PubMed:25578875}.
|