Gene Symbol | LTN1 |
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Entrez Gene | 26046 |
Alt Symbol | C21orf10, C21orf98, RNF160, ZNF294 |
Species | Human |
Gene Type | protein-coding |
Description | listerin E3 ubiquitin protein ligase 1 |
Other Description | E3 ubiquitin-protein ligase listerin|ring finger protein 160|zinc finger protein 294 |
Swissprots | A6NL41 O94822 Q9H8M4 Q05C47 A7E2D0 C9J7U3 Q9P0E9 Q9NUY5 B2RTS0 J3KPL4 |
Accessions | CAB90429 CAB90430 EAX09935 EAX09936 EAX09937 O94822 AB018257 BAA34434 AB621822 BAK64157 AF161350 AAF28910 AK001915 BAA91976 AK023499 BAB14589 BC007525 BC029371 AAH29371 BC031633 BC045726 BC140790 AAI40791 BC150284 AAI50285 BF059116 DB452437 XM_006723987 XP_006724050 XM_011529525 XP_011527827 NM_015565 NP_056380 |
Function | E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). {ECO:0000250|UniProtKB:Q04781, ECO:0000269|PubMed:23685075, ECO:0000269|PubMed:25132172, ECO:0000269|PubMed:25578875}. |
ZNF294 CRISPR/Cas9 KO Plasmid (h) - sc-404827 from Santa Cruz Biotechnology
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ZNF294 HDR Plasmid (h) - sc-404827-HDR from Santa Cruz Biotechnology
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ZNF294 Double Nickase Plasmid (h) - sc-404827-NIC from Santa Cruz Biotechnology
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ZNF294 Double Nickase Plasmid (h2) - sc-404827-NIC-2 from Santa Cruz Biotechnology
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ZNF294 CRISPR Activation Plasmid (h) - sc-404827-ACT from Santa Cruz Biotechnology
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ZNF294 CRISPR Activation Plasmid (h2) - sc-404827-ACT-2 from Santa Cruz Biotechnology
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ZNF294 Lentiviral Activation Particles (h) - sc-404827-LAC from Santa Cruz Biotechnology
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ZNF294 Lentiviral Activation Particles (h2) - sc-404827-LAC-2 from Santa Cruz Biotechnology
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ZNF294 siRNA (h) - sc-91401 from Santa Cruz Biotechnology
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ZNF294 shRNA Plasmid (h) - sc-91401-SH from Santa Cruz Biotechnology
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ZNF294 shRNA (h) Lentiviral Particles - sc-91401-V from Santa Cruz Biotechnology
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RNF160 RNAi - H00026046-R01 from Novus Biologicals
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MISSION® esiRNA - EHU126101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12823 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12823 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11149 from Sigma-Aldrich
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LTN1 siRNA (Human) - CRH8676 from Cohesion Biosciences
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shRNA set against Human LTN1 (NM_015565.2) - SHH335559 from Creative biogene
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Human LTN1 siRNA - orb269178 from Biorbyt
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LTN1 shRNA Plasmid (Human) - CHH8676 from Cohesion Biosciences
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