| Gene Symbol |
ITGB6
|
| Entrez Gene |
3694
|
| Alt Symbol |
AI1H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, beta 6
|
| Other Description |
integrin beta-6
|
| Swissprots |
P18564 B2R9W5 Q53RG5 Q16500 Q0VA95 Q53RR6 C9JA97
|
| Accessions |
AAB23690 AAX93093 AAY24053 CAA01832 EAX11390 P18564 AI264144 AK026736 AK290300 BAF82989 AK304203 BAG65080 AK313944 BAG36662 AL359053 AL831998 AM393800 CAL38675 BC121178 AAI21179 BC143656 CD013944 CD013945 CD013946 CD013947 DB222211 M35198 AAA36122 NM_000888 NP_000879 NM_001282353 NP_001269282 NM_001282354 NP_001269283 NM_001282355 NP_001269284 NM_001282388 NP_001269317 NM_001282389 NP_001269318 NM_001282390 NP_001269319
|
| Function |
Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. {ECO:0000269|PubMed:17545607}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|