VAV3

Gene Symbol	VAV3
Entrez Gene	10451
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	vav 3 guanine nucleotide exchange factor
Other Description	VAV-3|guanine nucleotide exchange factor VAV3|vav 3 oncogene
Swissprots	B1AMM0 Q9Y5X8 E9PQ97 B1APV5 O95230 O60498 B7ZLR1 B4E232 Q9UKW4
Accessions	EAW51251 EAW51252 Q9UKW4 AF035442 AAD03799 AF067817 AAC79695 AF118886 AAD20348 AF118887 AAD20349 AI304566 AK097750 AK295166 BAG58178 AK296537 BAH12381 AK300474 BAG62191 AK304088 BAG64994 AK316295 BAH14666 BC143969 AAI43970 BC146365 AAI46366 BC156726 AAI56727 DR002311 XM_005270360 XP_005270417 XM_005270361 XP_005270418 XM_011540502 XP_011538804 XM_011540503 XP_011538805 XM_011540504 XP_011538806 XM_011540505 XP_011538807 XM_011540506 XP_011538808 XR_946522 NM_001079874 NP_001073343 NM_006113 NP_006104
Function	Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adh
Tissue Specificity	Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:9705494}.
Top Pathways	cAMP signaling pathway, Focal adhesion, Chemokine signaling pathway, Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human VAV3 ELISA Kit (Cell-Based ELISA) - LS-F2381 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Guanine nucleotide exchange factor VAV3, VAV3, Human, ELISA Kit - E0219h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

VAV3 Colorimetric Cell-Based ELISA Kit - CB5719 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Guanine nucleotide exchange factor VAV3, VAV3, ELISA Kit - MBS9305972 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0pg/ml. Range 31.2pg/ml-1000pg/ml.

Vav 3 Oncogene (VAV3), ELISA Kit - MBS9312255 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human VAV3 ELISA Kit (Sandwich ELISA) - LS-F14030 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Guanine nucleotide exchange factor VAV3, VAV3, ELISA Kit - MBS9305767 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Guanine nucleotide exchange factor VAV3 ELISA Kit - abx253736 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Mouse VAV3 ELISA Kit (Sandwich ELISA) - LS-F13497 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

VAV3 ELISA Kit - DEIA-XYA1818 from Creative Diagnostics Category ELISA Kit

Human Guanine nucleotide exchange factor VAV3 ELISA Kit - EKE53535 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

VAV3 - EKH1556 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

VAV3 ELISA Kit (Human) : 96 Wells (OKEH00310) - OKEH00310 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human VAV3 ELISA Kit - E017755 from Biobool Category ELISA Kit

Human Guanine nucleotide exchange factor VAV3 ELISA Kit - EK1506 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.078ng/mL Range 0.156-10 ng/mL

anti-VAV3 antibody - ARG63630 from Arigo Biolaboratories Category ELISA Kit

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9355966 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9345519 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9357834 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9347512 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9359077 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9364856 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9345249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9346892 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine Nucleotide Exchange Factor VAV3 (VAV3), ELISA Kit - MBS9360897 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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