| Gene Symbol |
VAV3
|
| Entrez Gene |
10451
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vav 3 guanine nucleotide exchange factor
|
| Other Description |
VAV-3|guanine nucleotide exchange factor VAV3|vav 3 oncogene
|
| Swissprots |
B1AMM0 Q9Y5X8 E9PQ97 B1APV5 O95230 O60498 B7ZLR1 B4E232 Q9UKW4
|
| Accessions |
EAW51251 EAW51252 Q9UKW4 AF035442 AAD03799 AF067817 AAC79695 AF118886 AAD20348 AF118887 AAD20349 AI304566 AK097750 AK295166 BAG58178 AK296537 BAH12381 AK300474 BAG62191 AK304088 BAG64994 AK316295 BAH14666 BC143969 AAI43970 BC146365 AAI46366 BC156726 AAI56727 DR002311 XM_005270360 XP_005270417 XM_005270361 XP_005270418 XM_011540502 XP_011538804 XM_011540503 XP_011538805 XM_011540504 XP_011538806 XM_011540505 XP_011538807 XM_011540506 XP_011538808 XR_946522 NM_001079874 NP_001073343 NM_006113 NP_006104
|
| Function |
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adh
|
| Tissue Specificity |
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:9705494}.
|
| Top Pathways |
cAMP signaling pathway, Focal adhesion, Chemokine signaling pathway, Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration
|