VAV3

Gene Symbol VAV3
Entrez Gene 10451
Alt Symbol -
Species Human
Gene Type protein-coding
Description vav 3 guanine nucleotide exchange factor
Other Description VAV-3|guanine nucleotide exchange factor VAV3|vav 3 oncogene
Swissprots B1AMM0 Q9Y5X8 E9PQ97 B1APV5 O95230 O60498 B7ZLR1 B4E232 Q9UKW4
Accessions EAW51251 EAW51252 Q9UKW4 AF035442 AAD03799 AF067817 AAC79695 AF118886 AAD20348 AF118887 AAD20349 AI304566 AK097750 AK295166 BAG58178 AK296537 BAH12381 AK300474 BAG62191 AK304088 BAG64994 AK316295 BAH14666 BC143969 AAI43970 BC146365 AAI46366 BC156726 AAI56727 DR002311 XM_005270360 XP_005270417 XM_005270361 XP_005270418 XM_011540502 XP_011538804 XM_011540503 XP_011538805 XM_011540504 XP_011538806 XM_011540505 XP_011538807 XM_011540506 XP_011538808 XR_946522 NM_001079874 NP_001073343 NM_006113 NP_006104
Function Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adh
Tissue Specificity Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:9705494}.
Top Pathways cAMP signaling pathway, Focal adhesion, Chemokine signaling pathway, Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration

Vav3 Antibody - 2398 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, MCF-7 and HUVEC cells using Vav3 Antibody.

Vav3 (K-19) - sc-28474 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Vav3 (K-19): sc-28474. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic and membrane staining of glandular cells.

Anti-Vav proteins (phospho Y174) antibody - ab47282 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Vav proteins (phospho Y174) antibody (ab47282) at 1/500 dilutionLane 1 : Extrats from Jurkat cells treated with UV Lane 2 : Extrats from Jurkat cells untreatedLysates/proteins at 30 µg per lane.

Anti-Vav proteins antibody - ab92890 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation of VAV proteins from 500µg of Jurkat (Lane 1) and THP1 (Lane 2) cell lysates, using 2µg of ab92890.

Anti-Vav proteins antibody [EP482Y] - ab40875 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP482Y
Anti-Vav proteins antibody [EP482Y] (ab40875) at 1/2000 dilution + Jurkat cell lysate (10 ug).

Anti-VAV3 (phospho Y173) antibody - ab192590 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAV3 (phospho Y173) antibody (ab192590) at 1/500 dilutionLane 1 : Extracts from Jurkat cellsLane 2 : Extracts from Jurkat cells with antigen-specific peptide

Anti-VAV3 (phospho Y173) antibody [EPR1068A] - ab109544 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1068A
All lanes : Anti-VAV3 (phospho Y173) antibody [EPR1068A] (ab109544) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysate treated with PervanadateLysates/proteins at 10 µg per lane.

Anti-VAV3 antibody - ab21208 from Abcam

Prices $379.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-VAV3 antibody (ab21208) at 1 µg/ml + Human Bone Marrow lysate (35µg protein in RIPA buffer).

Anti-VAV3 antibody - ab118904 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry analysis (formalin-fixed, paraffin-embedded)of Human Skin stained with ab118904 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-VAV3 antibody - ab140680 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Human VAV3 by Western Blot and Immunoprecipitation.Samples: Whole cell lysate (50 µg for input; 1 mg for IP, 20% of IP loaded) from Jurkat cells. ab140680 used for WB at 1 µg/ml and used for IP at 6 µg/mg lysate.Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-VAV3 antibody - ab138286 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-VAV3 antibody (ab138286) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-VAV3 antibody [EP1130Y] - ab52938 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1130Y
Anti-VAV3 antibody [EP1130Y] (ab52938) at 1/100000 dilution + Jurkat cell lysate at 10 µgSecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-VAV3 Antibody (aa567-578) IHC-plus™ - LS-B3237 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-VAV3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3237 concentration 5 ug/ml.

Anti-VAV3 Antibody (aa566-590) - LS-C11018 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (phospho-Tyr173) - LS-C11020 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa566-591) - LS-C11019 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody - LS-C40173 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa118-167) - LS-C200813 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using VAV3 antibody.

Anti-VAV3 Antibody (aa398-583, Biotin) - LS-C299876 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa183-380, Biotin) - LS-C301256 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa398-583, FITC) - LS-C302035 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa183-380, FITC) - LS-C305077 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV3 Antibody (aa200-250) - LS-C290482 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human VAV3 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (50 ug for input; 1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-VAV3 antibody used for WB at 1 ug/ml and used for IP at 6 ug/mg lysate. VAV3 was also immunoprecipitated by rabbit anti-VAV3 antibody BL13957, which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-VAV3 Antibody (aa183-380) - LS-C296976 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant VAV3.

Anti-VAV3 Antibody (aa398-583) - LS-C296978 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant VAV3.
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