VAV3

Gene Symbol	VAV3
Entrez Gene	10451
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	vav 3 guanine nucleotide exchange factor
Other Description	VAV-3|guanine nucleotide exchange factor VAV3|vav 3 oncogene
Swissprots	B1AMM0 Q9Y5X8 E9PQ97 B1APV5 O95230 O60498 B7ZLR1 B4E232 Q9UKW4
Accessions	EAW51251 EAW51252 Q9UKW4 AF035442 AAD03799 AF067817 AAC79695 AF118886 AAD20348 AF118887 AAD20349 AI304566 AK097750 AK295166 BAG58178 AK296537 BAH12381 AK300474 BAG62191 AK304088 BAG64994 AK316295 BAH14666 BC143969 AAI43970 BC146365 AAI46366 BC156726 AAI56727 DR002311 XM_005270360 XP_005270417 XM_005270361 XP_005270418 XM_011540502 XP_011538804 XM_011540503 XP_011538805 XM_011540504 XP_011538806 XM_011540505 XP_011538807 XM_011540506 XP_011538808 XR_946522 NM_001079874 NP_001073343 NM_006113 NP_006104
Function	Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adh
Tissue Specificity	Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:9705494}.
Top Pathways	cAMP signaling pathway, Focal adhesion, Chemokine signaling pathway, Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VAV3 peptide - ab45613 from Abcam Category Peptide

VAV3 Antibody Blocking Peptide - LS-E25761 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAV3 blocking peptide - GTX89695-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Human Vav 3 Oncogene Protein - abx069658 from Abbexa Category Protein Source E.coli Species Human

Human Vav 3 Oncogene Protein - abx069657 from Abbexa Category Protein Source E.coli Species Human

VAV3 Peptide - AC21-0590-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Vav 3 Oncogene (VAV3), Human - 20-9034 from ARP American Research Products Category Protein Prices $869.00 Sizes 50 µg Source E.coli Species Human

Vav 3 Oncogene (VAV3), Human - 20-9035 from ARP American Research Products Category Protein Prices $869.00 Sizes 50 µg Source E.coli Species Human

VAV3 Peptide - 46-568P from ProSci Category Peptide Species Human

Recombinant Vav 3 Oncogene (VAV3) - RPE929Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Vav 3 Oncogene (VAV3) - RPE929Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Vav 3 Oncogene (VAV3) - RPE929Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Vav 3 Oncogene (VAV3) - RPE929Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Guanine nucleotide exchange factor VAV3(VAV3) ,partial - CSB-YP892140HU CSB-EP892140HU CSB-BP892140HU CSB-MP892140HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Vav3 (a.a. 293-305) - VX2705 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

Vav 3 Oncogene (VAV3) - RPU144341 from Biomatik Category Protein Prices $440.00, $880.00, $1,320.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

Vav 3 Oncogene (VAV3) - RPU144342 from Biomatik Category Protein Prices $440.00, $880.00, $1,320.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

VAV3 (transcript variant 2) - TP318352 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VAV3 (transcript variant 1) - TP320550 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Vav 3 Oncogene (VAV3), Recombinant Protein - MBS2012235 from MyBioSource Category Protein Prices $405.00, $765.00, $1,125.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Vav 3 Oncogene (VAV3), Recombinant Protein - MBS2011000 from MyBioSource Category Protein Prices $405.00, $765.00, $1,125.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

VAV3, Peptide - MBS426256 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

VAV3 Blocking Peptide - abx162074 from Abbexa Category Peptide Species Human, Mouse

VAV3 Recombinant Protein Antigen - NBP1-86382PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

VAV3-Blocking-Peptide-C-term - BP21626b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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