ENG

Gene Symbol	ENG
Entrez Gene	2022
Alt Symbol	END, HHT1, ORW1
Species	Human
Gene Type	protein-coding
Description	endoglin
Other Description	CD105 antigen
Swissprots	Q14926 Q14248 P17813 Q5T9C0
Accessions	AAC32802 AAC63386 ABI75346 EAW87702 EAW87703 EAW87704 P17813 AK222669 AK223044 BAD96764 AK290389 BAF83078 AK300156 BAG61940 AK301171 BAH13421 AK302455 BAG63750 BC014271 AAH14271 BC020391 BC031967 BT006872 AAP35518 DA943458 DB079257 DQ893673 ABM84599 DQ895827 ABM86753 J05481 AAA35800 X72012 CAA50891 NM_000118 NP_000109 NM_001114753 NP_001108225 NM_001278138 NP_001265067
Function	Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. {ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Endoglin is restricted to endothelial cells in all tissues except bone marrow.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD105 protein fragment - ab54338 from Abcam Category Protein Prices $122.00 Sizes 5 µg Source Insect cells Species Human

Active mouse CD105 protein fragment - ab54339 from Abcam Category Protein Prices $122.00 Sizes 5 µg Source Insect cells Species Mouse

Human CD105 full length protein - ab158361 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD105 full length protein - ab158362 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CD105 peptide - ab95043 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD105 protein fragment - ab185385 from Abcam Category Protein Prices $309.00 Sizes 10 µg Source E. coli Species Human

Human CD105 protein fragment - ab177604 from Abcam Category Protein Prices $301.00 Sizes 20 µg Source E. coli Species Human

Human CD105 protein fragment - ab193743 from Abcam Category Protein Prices $155.00 Sizes 10 µg Source Mammalian Species Human

Human CD105 protein fragment - ab194181 from Abcam Category Protein Prices $155.00 Sizes 10 µg Source Mammalian Species Human

Mouse CD105 protein fragment - ab123754 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

Endoglin/CD105 Recombinant Protein - H00002022-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Endoglin/CD105 Recombinant Protein - H00002022-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Endoglin/CD105 Protein - NBP1-99569 from Novus Biologicals Category Protein Prices $265.00 Sizes 10 µg Source Sf9 cells Species Human

ENG-Antibody-Center-Blocking-peptide - BP11239c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD105-Antibody-Center-E395-Blocking-Peptide - BP2880c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Endoglin/CD105 - 1097-EN-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu26-Gly586

Recombinant Human Endoglin/CD105, CF - 1097-EN-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu26-Gly586

Recombinant Human Endoglin/CD105 Fc Chimera, CF - 6578-EN-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Endoglin Protein (OPPA00651) - OPPA00651 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Sf9 Insect Cells

Endoglin Protein (OPPA01506) - OPPA01506 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human Endoglin protein - orb80304 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Human

Human endoglin protein - orb180255 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Mouse Endoglin protein - orb80305 from Biorbyt Category Protein Prices $170.00, $289.00, $961.00 Sizes 2 μg, 10 μg, 100 μg Source Insect Cells

ENG protein - orb197598 from Biorbyt Category Protein Prices $306.00, $493.00, $638.00 Sizes 10 μg, 50 μg, 100 μg Species Human

CD105 protein - 30R-ACD105x from Fitzgerald Category Protein Prices $375.00 Sizes 25 µg Source Sf-9 insect cells

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