| Gene Symbol | FKBP4 |
|---|---|
| Entrez Gene | 2288 |
| Alt Symbol | FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52 |
| Species | Human |
| Gene Type | protein-coding |
| Description | FK506 binding protein 4, 59kDa |
| Other Description | 51 kDa FK506-binding protein|FK506-binding protein 4 (59kD)|HSP binding immunophilin|T-cell FK506-binding protein, 59kD|peptidyl-prolyl cis-trans isomerase FKBP4|peptidylprolyl cis-trans isomerase|rotamase |
| Swissprots | Q9UCP1 D3DUQ1 Q9UCV7 Q02790 |
| Accessions | EAW88889 EAW88890 Q02790 AK024694 AK313918 BAG36639 BC001786 AAH01786 BC002887 BC007924 AAH07924 BQ083177 BQ446607 BU685040 DA392592 DQ893668 ABM84594 DQ895800 ABM86726 M88279 AAA36111 XM_011520929 XP_011519231 NM_002014 NP_002005 |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:1279700}. |
| Top Pathways | Estrogen signaling pathway |