FKBP4

Gene Symbol	FKBP4
Entrez Gene	2288
Alt Symbol	FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Species	Human
Gene Type	protein-coding
Description	FK506 binding protein 4, 59kDa
Other Description	51 kDa FK506-binding protein|FK506-binding protein 4 (59kD)|HSP binding immunophilin|T-cell FK506-binding protein, 59kD|peptidyl-prolyl cis-trans isomerase FKBP4|peptidylprolyl cis-trans isomerase|rotamase
Swissprots	Q9UCP1 D3DUQ1 Q9UCV7 Q02790
Accessions	EAW88889 EAW88890 Q02790 AK024694 AK313918 BAG36639 BC001786 AAH01786 BC002887 BC007924 AAH07924 BQ083177 BQ446607 BU685040 DA392592 DQ893668 ABM84594 DQ895800 ABM86726 M88279 AAA36111 XM_011520929 XP_011519231 NM_002014 NP_002005
Function	Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:1279700}.
Top Pathways	Estrogen signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human FKBP52 full length protein - ab84189 from Abcam Category Protein Prices $192.00 Sizes 25 µg Source E. coli Species Human

Active human FKBP52 full length protein - ab167973 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source E. coli Species Human

Human FKBP52 full length protein - ab185391 from Abcam Category Protein Source E. coli Species Human

Human FKBP52 peptide - ab61617 from Abcam Category Peptide

FKBP4 / FKBP52 Antibody Blocking Peptide - LS-E8914 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FKBP4 / FKBP52 Antibody Blocking Peptide - LS-E26944 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FKBP52/FKBP4 Protein - NBC1-22936 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

FKBP4/FKBP52 Partial Recombinant Protein - H00002288-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human FKBP52/FKBP4 Protein - H00002288-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FKBP52/FKBP4 Recombinant Protein - P3485 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

FKBP4-Antibody-Center-Blocking-Peptide - BP7387c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FKBP4 blocking peptide - GTX88487-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

FKBP4 Protein (OPPA02156) - OPPA02156 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human FK506 Binding Protein 4 protein - orb90096 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

Human FKBP4 protein - orb180369 from Biorbyt Category Protein Prices $204.00, $323.00, $1,411.00, $1,981.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

FKBP4 Blocking Peptide - 33R-1401 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FKBP4 protein (His tag) - 80R-1140 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

FKBP52 Blocking Peptide - 33R-10969 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

FKBP52 Peptide - AC21-1773-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FKBP4 (1-459, His-tag) - AR09172PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

FKBP4 (1-459, His-tag) - AR09172PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

FKBP4 - H00002288-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FKBP4 - H00002288-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FKBP4 - H00002288-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FKBP4 - H00002288-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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