FKBP4

Gene Symbol FKBP4
Entrez Gene 2288
Alt Symbol FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Species Human
Gene Type protein-coding
Description FK506 binding protein 4, 59kDa
Other Description 51 kDa FK506-binding protein|FK506-binding protein 4 (59kD)|HSP binding immunophilin|T-cell FK506-binding protein, 59kD|peptidyl-prolyl cis-trans isomerase FKBP4|peptidylprolyl cis-trans isomerase|rotamase
Swissprots Q9UCP1 D3DUQ1 Q9UCV7 Q02790
Accessions EAW88889 EAW88890 Q02790 AK024694 AK313918 BAG36639 BC001786 AAH01786 BC002887 BC007924 AAH07924 BQ083177 BQ446607 BU685040 DA392592 DQ893668 ABM84594 DQ895800 ABM86726 M88279 AAA36111 XM_011520929 XP_011519231 NM_002014 NP_002005
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:1279700}.
Top Pathways Estrogen signaling pathway

FKBP4 Antibody - 11826 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using FKBP4 Antibody.

HSP 56 (N-17) - sc-1803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HSP 56 (N-17): sc-1803. Western blot analysis of HSP 56 expression in HeLa whole cell lysate.

HSP 56 (P-14) - sc-11507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HSP 56 (P-14): sc-11507. Western blot analysis of HSP 56 expression in non-transfected 293: sc-110760 (A), mouse HSP 56 transfected 293: sc-110751 (B) and K-562 (C) whole cell lysates.

HSP 56 (329.1) - sc-100758 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HSP 56 (329.1): sc-100758. Western blot analysis of HSP 56 expression in HeLa whole cell lysate.

Anti-FKBP52 antibody - ab2926 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of FKBP52 (green) in HeLa cells. Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% BSA for 15 minutes at room temperature. Cells were probed without (left panel) or with (right panel) ab2926 (1:100) for at least 1 hour at room temperature, washed with PBS, and incubated with a DyLight 488-conjugated goat anti-rabbit IgG secondary antibody (1:400) for 30 minutes at room temperature. Nuclei (blue) were stained with Hoechst 33342 dye. Images were taken at 20X magnification.

Anti-FKBP52 antibody - ab54991 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP52 antibody - ab88617 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-FKBP52 antibody (ab88617) at 1 µg/ml + human liver tissue lysate at 50 µg

Anti-FKBP52 antibody - ab183763 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FKBP52 antibody (ab183763) at 1/5000 dilutionLane 1 : 293T whole cell lysate/extractLane 2 : HeLa whole cell lysate/extractLane 3 : HepG2 whole cell lysate/extractLysates/proteins at 30 µg per lane.

Anti-FKBP52 antibody - ab110191 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab110191, at 3.75 µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded Human Brain (Cerebellum) tissue by Immunohistochemistry.

Anti-FKBP52 antibody - ab81527 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-FKBP52 antibody (ab81527) at 0.01 µg/ml (for 1 hour) + Human Placenta lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-FKBP52 antibody [EPR6618] - ab129097 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6618
All lanes : Anti-FKBP52 antibody [EPR6618] (ab129097) at 1/1000 dilutionLane 1 : HeLa cell lysates Lane 2 : Jurkat cell lysates Lane 3 : K562 cell lysates Lane 4 : MCF7 cell lysates Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FKBP52 antibody [EPR6618] (Alexa Fluor® 488) - ab202764 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6618
ab202764 staining FKBP52 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab202764 at 1/200 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-FKBP52 antibody [EPR6619] - ab124906 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6619
All lanes : Anti-FKBP52 antibody [EPR6619] (ab124906) at 1/50000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLane 3 : Jurkat cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FKBP52 antibody [Hi52C] - ab59460 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Hi52C
ab59460 at 1/100 dilution staining FKBP52 in prostate tissue section by Immunohistochemistry (Bouin's fixative fixed paraffin-embedded tissue section). Antigen retrieval was done by microwave in citrate buffer. A HRP conjugated goat anti mouse secondary was used at 1/10 dilution.

Anti-FKBP4 / FKBP52 Antibody - LS-C15182 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP4 / FKBP52 Antibody (aa2-459) - LS-C36343 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FKBP4 / FKBP52 Antibody (clone KN382/EC1) - LS-C63288 from LifeSpan Bioscience

Prices $295.00, $495.00
Sizes 50 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone KN382/EC1

Anti-FKBP4 / FKBP52 Antibody (clone AT4D3) - LS-C103478 from LifeSpan Bioscience

Prices $255.00, $315.00
Sizes 50 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone AT4D3

Anti-FKBP4 / FKBP52 Antibody - LS-C123535 from LifeSpan Bioscience

Prices $365.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP4 / FKBP52 Antibody (aa301-411, clone 10C239, Azide-free) - LS-C183625 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C239

Anti-FKBP4 / FKBP52 Antibody (clone Hi52C, Atto 390) - LS-C227376 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Hi52C

Anti-FKBP4 / FKBP52 Antibody (clone Hi52C, Atto 565) - LS-C227377 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Hi52C

Anti-FKBP4 / FKBP52 Antibody (C-Terminus) - LS-C79944 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-FKBP4 / FKBP52 Antibody (clone Hi52C, Atto 594) - LS-C227378 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Hi52C

Anti-FKBP4 / FKBP52 Antibody (clone Hi52C, Atto 488) - LS-C227379 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Hi52C
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