FKBP4

Gene Symbol FKBP4
Entrez Gene 2288
Alt Symbol FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Species Human
Gene Type protein-coding
Description FK506 binding protein 4, 59kDa
Other Description 51 kDa FK506-binding protein|FK506-binding protein 4 (59kD)|HSP binding immunophilin|T-cell FK506-binding protein, 59kD|peptidyl-prolyl cis-trans isomerase FKBP4|peptidylprolyl cis-trans isomerase|rotamase
Swissprots Q9UCP1 D3DUQ1 Q9UCV7 Q02790
Accessions EAW88889 EAW88890 Q02790 AK024694 AK313918 BAG36639 BC001786 AAH01786 BC002887 BC007924 AAH07924 BQ083177 BQ446607 BU685040 DA392592 DQ893668 ABM84594 DQ895800 ABM86726 M88279 AAA36111 XM_011520929 XP_011519231 NM_002014 NP_002005
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:1279700}.
Top Pathways Estrogen signaling pathway

HSP 56 CRISPR/Cas9 KO Plasmid (h) - sc-403455 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 HDR Plasmid (h) - sc-403455-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 Double Nickase Plasmid (h) - sc-403455-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 Double Nickase Plasmid (h2) - sc-403455-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 CRISPR Activation Plasmid (h) - sc-403455-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 CRISPR Activation Plasmid (h2) - sc-403455-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 Lentiviral Activation Particles (h) - sc-403455-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 Lentiviral Activation Particles (h2) - sc-403455-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 56 siRNA (h) - sc-35602 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 56 shRNA Plasmid (h) - sc-35602-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 56 shRNA (h) Lentiviral Particles - sc-35602-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU104991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8716 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8716 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06034 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06034

FKBP4 siRNA (Human) - CRH1598 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FKBP52/FKBP4 RNAi - H00002288-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FKBP4 - MBS8218841 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FKBP4 (NM_002014.3) - SHH295253 from Creative biogene

Category siRNA
Species Reactivities Human

FKBP4 shRNA Plasmid (Human) - CHH1598 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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