ATP6AP2

Gene Symbol ATP6AP2
Entrez Gene 10159
Alt Symbol APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS
Species Human
Gene Type protein-coding
Description ATPase, H+ transporting, lysosomal accessory protein 2
Other Description ATPase H(+)-transporting lysosomal-interacting protein 2|ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9|ATPase, H+ transporting, lysosomal interacting protein 2|ER-localized type I transmembrane adaptor|N14F|V-ATPase M8.9 subunit|embryonic liver differentiation factor 10|prorenin receptor|renin receptor|renin/prorenin receptor|vacuolar ATP synthase membrane sector-associated protein M8-9|vacuolar proton ATP synthase membrane sector associated protein M8-9
Swissprots Q8NBP3 Q6T7F5 O75787 Q9UG89 Q9H2P8 Q96FV6 Q8NG15 B7Z9I3 Q5QTQ7 Q96LB5
Accessions AAL11062 EAW59424 O75787 AF109363 AAQ13511 AF248966 AAG44564 AF291814 AAM47531 AK075382 BAC11582 AK293510 BAH11525 AK296614 BAH12399 AK297007 BAH12473 AK297760 BAH12660 AK314633 AK315948 BAH14319 AL049929 CAB43210 AY038990 AAK83467 AY429341 AAR06910 BC010395 AAH10395 BC084541 AAH84541 Y17975 CAA76984 NM_005765 NP_005756
Function Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). {ECO:0000269|PubMed:12045255}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. {ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:15746149}.

Renin Receptor (H-85) - sc-67390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Renin Receptor (H-85): sc-67390. Western blot analysis of human recombinant Renin Receptor fusion protein.

Renin Receptor (K-19) - sc-55025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Renin Receptor (K-19): sc-55025. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of cells in molecular layer, cells in granular layer and Purkinje cells.

Renin Receptor (N-14) - sc-55026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ATP6IP2 antibody - ab64957 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab64957 at 1/50 dilution. Right hand panel was also treated with immunising peptide.

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, AP) - LS-C233002 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, APC) - LS-C233003 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (C-Terminus) - LS-C54556 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (0.5 ug/ml) of Human Kidney lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, Biotin) - LS-C233004 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, PE) - LS-C233010 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, FITC) - LS-C233005 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, Azide-free, HRP) - LS-C249492 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302, Biotin) - LS-C301096 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa171-220) - LS-C118716 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using Caper Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302, FITC) - LS-C304013 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa209-254) - LS-C313914 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234) - LS-C329239 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234) IHC-plus™ - LS-B9982 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ATP6AP2 / Renin Receptor antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9982 dilution 1:100.

Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302) - LS-C292950 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ATP6AP2 / Renin Receptor.

Anti-ATP6AP2 / Renin Receptor Antibody - LS-C346110 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using ATP6AP2 antibody. Blue: DAPI for nuclear staining.

Anti-ATP6AP2 / Renin Receptor Antibody - LS-C109539 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302) - LS-C126217 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-ATP6AP2 / Renin Receptor Antibody (aa325-375) - LS-C190180 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Renin R Antibody - NB100-1318 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Renin R Antibody [NB100-1318] - (0.5ug/ml) of Human Kidney lysate (RIPA buffer, 35ug total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence.

Renin R Antibody - NBP1-90820 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Renin R Antibody [NBP1-90820] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

Renin R Antibody - AF5716 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human and mouse heart tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Renin R Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5716) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Renin R at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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