Gene Symbol | ATP6AP2 |
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Entrez Gene | 10159 |
Alt Symbol | APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+ transporting, lysosomal accessory protein 2 |
Other Description | ATPase H(+)-transporting lysosomal-interacting protein 2|ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9|ATPase, H+ transporting, lysosomal interacting protein 2|ER-localized type I transmembrane adaptor|N14F|V-ATPase M8.9 subunit|embryonic liver differentiation factor 10|prorenin receptor|renin receptor|renin/prorenin receptor|vacuolar ATP synthase membrane sector-associated protein M8-9|vacuolar proton ATP synthase membrane sector associated protein M8-9 |
Swissprots | Q8NBP3 Q6T7F5 O75787 Q9UG89 Q9H2P8 Q96FV6 Q8NG15 B7Z9I3 Q5QTQ7 Q96LB5 |
Accessions | AAL11062 EAW59424 O75787 AF109363 AAQ13511 AF248966 AAG44564 AF291814 AAM47531 AK075382 BAC11582 AK293510 BAH11525 AK296614 BAH12399 AK297007 BAH12473 AK297760 BAH12660 AK314633 AK315948 BAH14319 AL049929 CAB43210 AY038990 AAK83467 AY429341 AAR06910 BC010395 AAH10395 BC084541 AAH84541 Y17975 CAA76984 NM_005765 NP_005756 |
Function | Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). {ECO:0000269|PubMed:12045255}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. {ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:15746149}. |
Renin Receptor (H-85) - sc-67390 from Santa Cruz Biotechnology
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Renin Receptor (K-19) - sc-55025 from Santa Cruz Biotechnology
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Renin Receptor (N-14) - sc-55026 from Santa Cruz Biotechnology
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Anti-ATP6IP2 antibody - ab64957 from Abcam
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, AP) - LS-C233002 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, APC) - LS-C233003 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (C-Terminus) - LS-C54556 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, Biotin) - LS-C233004 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, PE) - LS-C233010 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, FITC) - LS-C233005 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234, Azide-free, HRP) - LS-C249492 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302, Biotin) - LS-C301096 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa171-220) - LS-C118716 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302, FITC) - LS-C304013 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa209-254) - LS-C313914 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234) - LS-C329239 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa205-234) IHC-plus™ - LS-B9982 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302) - LS-C292950 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody - LS-C346110 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody - LS-C109539 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa17-302) - LS-C126217 from LifeSpan Bioscience
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Anti-ATP6AP2 / Renin Receptor Antibody (aa325-375) - LS-C190180 from LifeSpan Bioscience
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Renin R Antibody - NB100-1318 from Novus Biologicals
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Renin R Antibody - NBP1-90820 from Novus Biologicals
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Renin R Antibody - AF5716 from Novus Biologicals
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