| Gene Symbol |
ATP6AP2
|
| Entrez Gene |
10159
|
| Alt Symbol |
APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, H+ transporting, lysosomal accessory protein 2
|
| Other Description |
ATPase H(+)-transporting lysosomal-interacting protein 2|ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9|ATPase, H+ transporting, lysosomal interacting protein 2|ER-localized type I transmembrane adaptor|N14F|V-ATPase M8.9 subunit|embryonic liver differentiation factor 10|prorenin receptor|renin receptor|renin/prorenin receptor|vacuolar ATP synthase membrane sector-associated protein M8-9|vacuolar proton ATP synthase membrane sector associated protein M8-9
|
| Swissprots |
Q8NBP3 Q6T7F5 O75787 Q9UG89 Q9H2P8 Q96FV6 Q8NG15 B7Z9I3 Q5QTQ7 Q96LB5
|
| Accessions |
AAL11062 EAW59424 O75787 AF109363 AAQ13511 AF248966 AAG44564 AF291814 AAM47531 AK075382 BAC11582 AK293510 BAH11525 AK296614 BAH12399 AK297007 BAH12473 AK297760 BAH12660 AK314633 AK315948 BAH14319 AL049929 CAB43210 AY038990 AAK83467 AY429341 AAR06910 BC010395 AAH10395 BC084541 AAH84541 Y17975 CAA76984 NM_005765 NP_005756
|
| Function |
Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). {ECO:0000269|PubMed:12045255}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. {ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:15746149}.
|