| Gene Symbol |
QSOX2
|
| Entrez Gene |
169714
|
| Alt Symbol |
QSCN6L1, SOXN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
quiescin Q6 sulfhydryl oxidase 2
|
| Other Description |
neuroblastoma-derived sulfhydryl oxidase|quiescin Q6-like 1|quiescin Q6-like protein 1|sulfhydryl oxidase 2
|
| Swissprots |
Q7Z7B6 Q8N3G2 Q86VV7 Q6ZRP7 Q5TB37 A6NLB0 A2CEE0
|
| Accessions |
EAW88207 EAW88208 EAW88209 Q6ZRP7 AJ318051 CAC85331 AJ420461 AK128077 BAC87262 AK128750 BAG54726 AL834369 CAD39032 BC047604 AAH47604 BQ269870 DQ575499 NM_181701 NP_859052
|
| Function |
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:14633699}; Single-pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
|
| Tissue Specificity |
Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. {ECO:0000269|PubMed:14633699}.
|