Gene Symbol | QSOX2 |
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Entrez Gene | 169714 |
Alt Symbol | QSCN6L1, SOXN |
Species | Human |
Gene Type | protein-coding |
Description | quiescin Q6 sulfhydryl oxidase 2 |
Other Description | neuroblastoma-derived sulfhydryl oxidase|quiescin Q6-like 1|quiescin Q6-like protein 1|sulfhydryl oxidase 2 |
Swissprots | Q7Z7B6 Q8N3G2 Q86VV7 Q6ZRP7 Q5TB37 A6NLB0 A2CEE0 |
Accessions | EAW88207 EAW88208 EAW88209 Q6ZRP7 AJ318051 CAC85331 AJ420461 AK128077 BAC87262 AK128750 BAG54726 AL834369 CAD39032 BC047604 AAH47604 BQ269870 DQ575499 NM_181701 NP_859052 |
Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:14633699}; Single-pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane. |
Tissue Specificity | Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. {ECO:0000269|PubMed:14633699}. |
SOXN CRISPR/Cas9 KO Plasmid (h) - sc-414917 from Santa Cruz Biotechnology
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SOXN HDR Plasmid (h) - sc-414917-HDR from Santa Cruz Biotechnology
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SOXN Double Nickase Plasmid (h) - sc-414917-NIC from Santa Cruz Biotechnology
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SOXN Double Nickase Plasmid (h2) - sc-414917-NIC-2 from Santa Cruz Biotechnology
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SOXN CRISPR Activation Plasmid (h) - sc-414917-ACT from Santa Cruz Biotechnology
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SOXN CRISPR Activation Plasmid (h2) - sc-414917-ACT-2 from Santa Cruz Biotechnology
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SOXN Lentiviral Activation Particles (h) - sc-414917-LAC from Santa Cruz Biotechnology
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SOXN Lentiviral Activation Particles (h2) - sc-414917-LAC-2 from Santa Cruz Biotechnology
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SOXN siRNA (h) - sc-92548 from Santa Cruz Biotechnology
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SOXN shRNA Plasmid (h) - sc-92548-SH from Santa Cruz Biotechnology
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SOXN shRNA (h) Lentiviral Particles - sc-92548-V from Santa Cruz Biotechnology
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QSOX2 RNAi - H00169714-R01 from Novus Biologicals
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MISSION® esiRNA - EHU080261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17794 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17794 from Sigma-Aldrich
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QSOX2 siRNA (Human) - CRJ6091 from Cohesion Biosciences
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QSOX2 - MBS8212834 from MyBioSource
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shRNA set against Human Qsox2 (NM_181701.3) - SHH387708 from Creative biogene
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shRNA set against Human QSCN6L1(NM_181701.3) - SHR156890 from Creative biogene
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Human QSOX2 siRNA - orb276592 from Biorbyt
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QSOX2 shRNA Plasmid (Human) - CHJ6091 from Cohesion Biosciences
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QSOX2 miRNA 3'UTR clone - MiUTR1H-08535 from Creative biogene
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