| Gene Symbol |
FBXW11
|
| Entrez Gene |
23291
|
| Alt Symbol |
BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and WD repeat domain containing 11
|
| Other Description |
F-box and WD repeats protein beta-TrCP2|F-box and WD-40 domain protein 11|F-box and WD-40 domain protein 1B|F-box protein Fbw1b|F-box/WD repeat-containing protein 11|F-box/WD repeat-containing protein 1B|beta-transducin repeat-containing protein 2|homologous to Slimb protein
|
| Swissprots |
Q9P2S9 Q9Y4C6 Q9UKB1 B2RC98 Q9P2S8
|
| Accessions |
EAW61440 Q9UKB1 AB014596 BAA31671 AB033279 BAA92329 AB033280 BAA92330 AB033281 BAA92331 AF176022 AAF04528 AK294956 BAG58031 AK314999 BAG37495 BC026213 AAH26213 DQ891125 ABM82051 DQ894304 ABM85230 XM_005265855 XP_005265912 XM_005265856 XP_005265913 XM_005265857 XP_005265914 XM_005265858 XP_005265915 XM_011534492 XP_011532794 NM_012300 NP_036432 NM_033644 NP_387448 NM_033645 NP_387449
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress- induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Top Pathways |
Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis
|
![Western Blot: FBXW11 Overexpression Lysate (Adult Normal) [NBL1-10644] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FBXW11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3457_FBXW11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10644-img0002.jpg)