FBXW11

Gene Symbol FBXW11
Entrez Gene 23291
Alt Symbol BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
Species Human
Gene Type protein-coding
Description F-box and WD repeat domain containing 11
Other Description F-box and WD repeats protein beta-TrCP2|F-box and WD-40 domain protein 11|F-box and WD-40 domain protein 1B|F-box protein Fbw1b|F-box/WD repeat-containing protein 11|F-box/WD repeat-containing protein 1B|beta-transducin repeat-containing protein 2|homologous to Slimb protein
Swissprots Q9P2S9 Q9Y4C6 Q9UKB1 B2RC98 Q9P2S8
Accessions EAW61440 Q9UKB1 AB014596 BAA31671 AB033279 BAA92329 AB033280 BAA92330 AB033281 BAA92331 AF176022 AAF04528 AK294956 BAG58031 AK314999 BAG37495 BC026213 AAH26213 DQ891125 ABM82051 DQ894304 ABM85230 XM_005265855 XP_005265912 XM_005265856 XP_005265913 XM_005265857 XP_005265914 XM_005265858 XP_005265915 XM_011534492 XP_011532794 NM_012300 NP_036432 NM_033644 NP_387448 NM_033645 NP_387449
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress- induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Top Pathways Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

Human-FBXW11-cDNA-Clone - DC05589 from Abgent, a WuXi AppTec company

Prices $714.15
Sizes 10 µg
Species Human
Accession BC026213

FBXW11 - MBS1277150 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC026213

Human FBXW11 cDNA clone(NM_033644.2) - CDFG006935 from Creative Biomart

Species Human
Accession NM_033644.2

Human FBXW11 cDNA clone(NM_033645.2) - CDFG006936 from Creative Biomart

Species Human
Accession NM_033645.2

Human FBXW11 cDNA clone(NM_033644.2) - CDFG006938 from Creative Biomart

Species Human
Accession NM_033644.2

Human FBXW11 cDNA clone(NM_012300.2) - CDFH006706 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 cDNA clone(NM_012300.2) - CDFH006707 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 ORF Clone(NM_012300.2) - CDCL163312 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 ORF Clone(NM_012300.2) - CDCL163313 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 ORF clone - CDCL107461 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF clone - CDCL107462 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF clone - CDCL107463 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF clone - CDCL107464 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF clone - CDCL107465 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF clone - CDCL107466 from Creative Biomart

Species Human
Accession NM_012300

Human FBXW11 ORF Clone(NM_012300.2) - CDCR295796 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 ORF Clone(NM_012300.2) - CDCR295797 from Creative Biomart

Species Human
Accession NM_012300.2

Human FBXW11 ORF Clone(NM_033644.2) - CDCR313959 from Creative Biomart

Species Human
Accession NM_033644.2

Human FBXW11 ORF Clone(NM_033644.2) - CDCR313960 from Creative Biomart

Species Human
Accession NM_033644.2

Human FBXW11 ORF Clone(NM_033644.2) - CDCR314121 from Creative Biomart

Species Human
Accession NM_033644.2

Human FBXW11 ORF Clone(NM_033645.2) - CDCR314122 from Creative Biomart

Species Human
Accession NM_033645.2

Human FBXW11 ORF Clone(NM_033645.2) - CDCR314123 from Creative Biomart

Species Human
Accession NM_033645.2

Human FBXW11 ORF Clone(NM_033645.2) - CDCR314124 from Creative Biomart

Species Human
Accession NM_033645.2

Human FBXW11 ORF Clone(NM_033644.2) - CDCR313960 from Creative biogene

Species Human

Human FBXW11 ORF Clone(NM_033645.2) - CDCR314122 from Creative biogene

Species Human
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