FBXW11

Gene Symbol	FBXW11
Entrez Gene	23291
Alt Symbol	BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 11
Other Description	F-box and WD repeats protein beta-TrCP2\|F-box and WD-40 domain protein 11\|F-box and WD-40 domain protein 1B\|F-box protein Fbw1b\|F-box/WD repeat-containing protein 11\|F-box/WD repeat-containing protein 1B\|beta-transducin repeat-containing protein 2\|homologous to Slimb protein
Swissprots	Q9P2S9 Q9Y4C6 Q9UKB1 B2RC98 Q9P2S8
Accessions	EAW61440 Q9UKB1 AB014596 BAA31671 AB033279 BAA92329 AB033280 BAA92330 AB033281 BAA92331 AF176022 AAF04528 AK294956 BAG58031 AK314999 BAG37495 BC026213 AAH26213 DQ891125 ABM82051 DQ894304 ABM85230 XM_005265855 XP_005265912 XM_005265856 XP_005265913 XM_005265857 XP_005265914 XM_005265858 XP_005265915 XM_011534492 XP_011532794 NM_012300 NP_036432 NM_033644 NP_387448 NM_033645 NP_387449
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress- induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

β-TrCP/HOS (E-20) - sc-9599 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-beta TRCP2 antibody - ab154070 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-beta TRCP2 antibody (ab154070) at 1/2000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-beta TRCP2 antibody - ab170251 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed paraffin embedded Human fetal brain tissue labeling beta TRCP2 with ab170251 at 1/100 dilution.

Anti-FBXW11 Antibody (N-Terminus) - LS-C60083 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-bTrCP2 Antibody - Western Blot. Western blot of affinity purified anti-bTrCP2 antibody shows detection of mouse and human bTrCP2 (arrowhead) in NIH3T3 (lane 1) and 293 (lane 2) whole cell lysates, respectively. The band appears as a 58 kD protein, although a 62.1 kD band is predicted. The identity of faint higher molecular weight bands is not known. The primary antibody was used at a 1:200 dilution incubated in 5% BLOTTO overnight at 4C. Detection occurred using HRP conjugated Goat-anti-Rabbit IgG (LS-C60865) diluted 1:20000 in blocking buffer (p/n MB-070) for 1 h at 4C.

Anti-FBXW11 Antibody - LS-C109367 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa168-196, AP) - LS-C222527 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa168-196, FITC) - LS-C222530 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa38-87) - LS-C80549 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-FBXW11 Antibody (aa168-196, Azide-free, HRP) - LS-C222529 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (N-Terminus) - LS-C80570 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-FBXW11 Antibody (aa168-196, PE) - LS-C222533 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa168-196, Biotin) - LS-C222531 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa168-196, APC) - LS-C222528 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody - LS-C308007 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-FBXW11 Antibody (aa175-204) - LS-C321330 from LifeSpan Bioscience

Prices	$435.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 Antibody (aa168-196) - LS-C166093 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

FBXW11 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

FBXW11 Antibody - NBP1-78060 from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

FBXW11 Antibody - NBP2-16454 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: FBXW11 Antibody [NBP2-16454] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC C: BCL-1 7. 5% SDS PAGE gel, diluted at 1:1000.

FBXW11 Antibody - NBP1-55069 from Novus Biologicals

Prices	$369.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: FBXW11 Antibody [NBP1-55069] - 293T cells lysate, concentration 0.2-1 ug/ml.

FBXW11 Antibody - NBP1-55052 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: FBXW11 Antibody [NBP1-55052] - Titration: 0.2-1 ug/ml, Positive Control: 721_B cell lysate.

FBXW11 Antibody - NBP1-33738 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: FBXW11 Antibody [NBP1-33738] - A: H1299.

FBXW11 Antibody (2E7) - H00023291-M03 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2E7

Immunocytochemistry/Immunofluorescence: FBXW11 Antibody (2E7) [H00023291-M03] - Analysis of monoclonal antibody to FBXW11 on HeLa cell. Antibody concentration 10 ug/ml

BTRC2 Polyclonal Antibody - bs-8387R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 (ab2) antibody produced in rabbit - SAB2100799 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FBXW11 antibody produced in rabbit - SAB2702077 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-FBXW11: <B>Cat. No. SAB2702077</B>: Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using FBXW11 antibody at 1:100 dilution.

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