FBXW11

Gene Symbol	FBXW11
Entrez Gene	23291
Alt Symbol	BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 11
Other Description	F-box and WD repeats protein beta-TrCP2|F-box and WD-40 domain protein 11|F-box and WD-40 domain protein 1B|F-box protein Fbw1b|F-box/WD repeat-containing protein 11|F-box/WD repeat-containing protein 1B|beta-transducin repeat-containing protein 2|homologous to Slimb protein
Swissprots	Q9P2S9 Q9Y4C6 Q9UKB1 B2RC98 Q9P2S8
Accessions	EAW61440 Q9UKB1 AB014596 BAA31671 AB033279 BAA92329 AB033280 BAA92330 AB033281 BAA92331 AF176022 AAF04528 AK294956 BAG58031 AK314999 BAG37495 BC026213 AAH26213 DQ891125 ABM82051 DQ894304 ABM85230 XM_005265855 XP_005265912 XM_005265856 XP_005265913 XM_005265857 XP_005265914 XM_005265858 XP_005265915 XM_011534492 XP_011532794 NM_012300 NP_036432 NM_033644 NP_387448 NM_033645 NP_387449
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress- induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human beta TRCP2 full length protein - ab161589 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

FBXW11 Antibody Blocking Peptide - LS-E840 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXW11 Antibody Blocking Peptide - LS-E15961 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBXW11 Protein - H00023291-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXW11 Peptide - NBP1-96762 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

FBXW11-Antibody-Center-Blocking-peptide - BP11217c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXW11 Blocking Peptide - 33R-2627 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXW11 Blocking Peptide - 33R-1744 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBW1B - H00023291-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBW1B - H00023291-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBW1B Control Peptide - AP09238CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

FBXW11 fusion protein - Ag3761 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FBXW11, GST-tagged - FBXW11-12808H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human F-box/WD repeat-containing protein 11(FBXW11) - CSB-YP891721HU CSB-EP891721HU CSB-BP891721HU CSB-MP891721HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXW11 Protein - abx164563 from Abbexa Category Protein Species Human, Mouse

FBW1B (transcript variant 2) - TP304407 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FBXW11 Peptide, Human - M34GP05622H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box/WD repeat-containing protein 11 (FBXW11), Recombinant Protein - MBS1464414 from MyBioSource Category Protein Prices $1,335.00, $1,335.00, $1,555.00, $1,555.00, $2,210.00, $2,210.00, $2,675.00, $2,675.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FBXW11 Recombinant Protein Antigen - NBP2-58829PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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