| Gene Symbol |
GPR31
|
| Entrez Gene |
2853
|
| Alt Symbol |
12-HETER, HETER, HETER1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 31
|
| Other Description |
12-(S)-HETE acid receptor|12-(S)-HETE receptor|12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor|12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor|G-protein coupled receptor 31|bA517H2.2 (G protein-coupled receptor 31)|hydroxyeicosatetraenoic (HETE) acid receptor 1|probable G-protein coupled receptor 31
|
| Swissprots |
Q9NQ20 B0M0K2 Q4VBL3 O00270
|
| Accessions |
AAC51375 ABY87916 EAW47505 O00270 BC095537 AAH95537 BC167778 AAI67778 CD246167 NM_005299 NP_005290
|
| Function |
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. {ECO:0000269|PubMed:21712392}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21712392}; Multi-pass membrane protein {ECO:0000269|PubMed:21712392}.
|