Gene Symbol | GPR31 |
---|---|
Entrez Gene | 2853 |
Alt Symbol | 12-HETER, HETER, HETER1 |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor 31 |
Other Description | 12-(S)-HETE acid receptor|12-(S)-HETE receptor|12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor|12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor|G-protein coupled receptor 31|bA517H2.2 (G protein-coupled receptor 31)|hydroxyeicosatetraenoic (HETE) acid receptor 1|probable G-protein coupled receptor 31 |
Swissprots | Q9NQ20 B0M0K2 Q4VBL3 O00270 |
Accessions | AAC51375 ABY87916 EAW47505 O00270 BC095537 AAH95537 BC167778 AAI67778 CD246167 NM_005299 NP_005290 |
Function | High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. {ECO:0000269|PubMed:21712392}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21712392}; Multi-pass membrane protein {ECO:0000269|PubMed:21712392}. |
GPR31 CRISPR/Cas9 KO Plasmid (h) - sc-407920 from Santa Cruz Biotechnology
|
||||||||
GPR31 HDR Plasmid (h) - sc-407920-HDR from Santa Cruz Biotechnology
|
||||||||
GPR31 Double Nickase Plasmid (h) - sc-407920-NIC from Santa Cruz Biotechnology
|
||||||||
GPR31 Double Nickase Plasmid (h2) - sc-407920-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GPR31 CRISPR Activation Plasmid (h) - sc-407920-ACT from Santa Cruz Biotechnology
|
||||||||
GPR31 CRISPR Activation Plasmid (h2) - sc-407920-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GPR31 Lentiviral Activation Particles (h) - sc-407920-LAC from Santa Cruz Biotechnology
|
||||||||
GPR31 Lentiviral Activation Particles (h2) - sc-407920-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GPR31 siRNA (h) - sc-95170 from Santa Cruz Biotechnology
|
||||||||
GPR31 shRNA Plasmid (h) - sc-95170-SH from Santa Cruz Biotechnology
|
||||||||
GPR31 shRNA (h) Lentiviral Particles - sc-95170-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU136791 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN9599 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9599 from Sigma-Aldrich
|
||||||||
GPR31 siRNA (Human) - CRH1915 from Cohesion Biosciences
|
||||||||
GPR31 RNAi - H00002853-R02 from Novus Biologicals
|
||||||||
GPR31 - MBS8238529 from MyBioSource
|
||||||||
shRNA set against Human GPR31 (NM_005299.2) - SHH306762 from Creative biogene
|
||||||||
Human GPR31 siRNA - orb262417 from Biorbyt
|
||||||||
GPR31 shRNA Plasmid (Human) - CHH1915 from Cohesion Biosciences
|
||||||||
GPR31 miRNA 3'UTR clone - MiUTR1H-04212 from Creative biogene
|