STK3

Gene Symbol	STK3
Entrez Gene	6788
Alt Symbol	KRS1, MST2
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 3
Other Description	KB-1458E12.1|MST-2|STE20-like kinase MST2|mammalian STE20-like protein kinase 2|serine/threonine kinase 3 (STE20 homolog, yeast)|serine/threonine kinase 3 (Ste20, yeast homolog)|serine/threonine-protein kinase 3|serine/threonine-protein kinase Krs-1
Swissprots	B3KYA7 Q15445 A8K722 Q13188 Q96FM6 Q15801
Accessions	EAW91781 Q13188 AA370619 AK075229 BAC11487 AK131363 BAG54769 AK291837 BAF84526 AK307787 AK312660 BC010640 AAH10640 CR627416 HG501506 U26424 AAC50386 U60206 AAB17261 Z25422 CAA80909 XM_011517247 XP_011515549 XM_011517248 XP_011515550 XM_011517249 XP_011515551 XM_011517250 XP_011515552 XM_011517251 XP_011515553 XM_011517252 XP_011515554 XM_011517253 XP_011515555 XM_011517254 XP_011515556 XM_011517255 XP_011515557 XM_011517256 XP_011515558 XM_011517257 XP_011515559 XM_011517258 XP_011515560 NM_001256312 NP_001243241 NM_001256313 NP_001243242 NM_006281 NP_006272
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. {ECO:0000250, ECO:0000269|PubMed:19525978}.
Tissue Specificity	Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. {ECO:0000269|PubMed:8566796}.
Top Pathways	MAPK signaling pathway, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MST2 Antibody - 3952 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Krs-1 (C-19) - sc-6211 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Krs-1 (H-35) - sc-292269 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Krs-1 (N-19) - sc-6212 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Krs-1 (87.K) - sc-130405 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-MST1/MST2 (phospho T180 + T183) antibody [EPR1467Y] - ab76323 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1467Y

Anti-MST1/MST2 (phospho T183) antibody - ab79199 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MST1/MST2 antibody - ab87322 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-STK3 antibody - ab124226 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-STK3 antibody [3067C3a] - ab71960 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3067C3a

Anti-STK3 antibody [EP1466Y] - ab52641 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1466Y

Anti-STK3 Antibody - LS-C48637 from LifeSpan Bioscience Prices $410.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody - LS-C76050 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-STK3 Antibody (aa386-415, AP) - LS-C270565 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (Internal) - LS-C154966 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-STK3 Antibody (N-Terminus) - LS-C81280 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415, APC) - LS-C270566 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415, FITC) - LS-C270568 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415, Biotin) - LS-C270567 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415, Azide-free, HRP) - LS-C270569 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415, PE) - LS-C270571 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (clone 3067C3a) - LS-C184663 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3067C3a

Anti-STK3 Antibody (aa351-400) - LS-C81281 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa400-450) - LS-C287350 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-STK3 Antibody (aa386-415) - LS-C325453 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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