STK3

Gene Symbol	STK3
Entrez Gene	6788
Alt Symbol	KRS1, MST2
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 3
Other Description	KB-1458E12.1|MST-2|STE20-like kinase MST2|mammalian STE20-like protein kinase 2|serine/threonine kinase 3 (STE20 homolog, yeast)|serine/threonine kinase 3 (Ste20, yeast homolog)|serine/threonine-protein kinase 3|serine/threonine-protein kinase Krs-1
Swissprots	B3KYA7 Q15445 A8K722 Q13188 Q96FM6 Q15801
Accessions	EAW91781 Q13188 AA370619 AK075229 BAC11487 AK131363 BAG54769 AK291837 BAF84526 AK307787 AK312660 BC010640 AAH10640 CR627416 HG501506 U26424 AAC50386 U60206 AAB17261 Z25422 CAA80909 XM_011517247 XP_011515549 XM_011517248 XP_011515550 XM_011517249 XP_011515551 XM_011517250 XP_011515552 XM_011517251 XP_011515553 XM_011517252 XP_011515554 XM_011517253 XP_011515555 XM_011517254 XP_011515556 XM_011517255 XP_011515557 XM_011517256 XP_011515558 XM_011517257 XP_011515559 XM_011517258 XP_011515560 NM_001256312 NP_001243241 NM_001256313 NP_001243242 NM_006281 NP_006272
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. {ECO:0000250, ECO:0000269|PubMed:19525978}.
Tissue Specificity	Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. {ECO:0000269|PubMed:8566796}.
Top Pathways	MAPK signaling pathway, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Krs-1 CRISPR/Cas9 KO Plasmid (h) - sc-416738 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 HDR Plasmid (h) - sc-416738-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 Double Nickase Plasmid (h) - sc-416738-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 Double Nickase Plasmid (h2) - sc-416738-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 CRISPR Activation Plasmid (h) - sc-416738-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 CRISPR Activation Plasmid (h2) - sc-416738-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 Lentiviral Activation Particles (h) - sc-416738-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 Lentiviral Activation Particles (h2) - sc-416738-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-1 siRNA (h) - sc-39247 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Krs-1 shRNA Plasmid (h) - sc-39247-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Krs-1 shRNA (h) Lentiviral Particles - sc-39247-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MST2/STK3 RNAi - H00006788-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU083271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2159 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2160 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2161 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN20736 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20736 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08509 from Sigma-Aldrich Category miRNA

STK3 siRNA (Human) - CRH4644 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK3 - MBS8214657 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human STK3 (NM_006281.3) - SHH419776 from Creative biogene Category siRNA Species Reactivities Human

Human STK3 siRNA - orb265146 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK3 shRNA Plasmid (Human) - CHH4644 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

STK3 miRNA 3'UTR clone - MiUTR3H-07303 from Creative biogene Species Reactivities Human

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