| Gene Symbol |
STK3
|
| Entrez Gene |
6788
|
| Alt Symbol |
KRS1, MST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine kinase 3
|
| Other Description |
KB-1458E12.1|MST-2|STE20-like kinase MST2|mammalian STE20-like protein kinase 2|serine/threonine kinase 3 (STE20 homolog, yeast)|serine/threonine kinase 3 (Ste20, yeast homolog)|serine/threonine-protein kinase 3|serine/threonine-protein kinase Krs-1
|
| Swissprots |
B3KYA7 Q15445 A8K722 Q13188 Q96FM6 Q15801
|
| Accessions |
EAW91781 Q13188 AA370619 AK075229 BAC11487 AK131363 BAG54769 AK291837 BAF84526 AK307787 AK312660 BC010640 AAH10640 CR627416 HG501506 U26424 AAC50386 U60206 AAB17261 Z25422 CAA80909 XM_011517247 XP_011515549 XM_011517248 XP_011515550 XM_011517249 XP_011515551 XM_011517250 XP_011515552 XM_011517251 XP_011515553 XM_011517252 XP_011515554 XM_011517253 XP_011515555 XM_011517254 XP_011515556 XM_011517255 XP_011515557 XM_011517256 XP_011515558 XM_011517257 XP_011515559 XM_011517258 XP_011515560 NM_001256312 NP_001243241 NM_001256313 NP_001243242 NM_006281 NP_006272
|
| Function |
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. {ECO:0000250, ECO:0000269|PubMed:19525978}.
|
| Tissue Specificity |
Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. {ECO:0000269|PubMed:8566796}.
|
| Top Pathways |
MAPK signaling pathway, Hippo signaling pathway
|