STK3

Gene Symbol	STK3
Entrez Gene	6788
Alt Symbol	KRS1, MST2
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 3
Other Description	KB-1458E12.1|MST-2|STE20-like kinase MST2|mammalian STE20-like protein kinase 2|serine/threonine kinase 3 (STE20 homolog, yeast)|serine/threonine kinase 3 (Ste20, yeast homolog)|serine/threonine-protein kinase 3|serine/threonine-protein kinase Krs-1
Swissprots	B3KYA7 Q15445 A8K722 Q13188 Q96FM6 Q15801
Accessions	EAW91781 Q13188 AA370619 AK075229 BAC11487 AK131363 BAG54769 AK291837 BAF84526 AK307787 AK312660 BC010640 AAH10640 CR627416 HG501506 U26424 AAC50386 U60206 AAB17261 Z25422 CAA80909 XM_011517247 XP_011515549 XM_011517248 XP_011515550 XM_011517249 XP_011515551 XM_011517250 XP_011515552 XM_011517251 XP_011515553 XM_011517252 XP_011515554 XM_011517253 XP_011515555 XM_011517254 XP_011515556 XM_011517255 XP_011515557 XM_011517256 XP_011515558 XM_011517257 XP_011515559 XM_011517258 XP_011515560 NM_001256312 NP_001243241 NM_001256313 NP_001243242 NM_006281 NP_006272
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. {ECO:0000250, ECO:0000269|PubMed:19525978}.
Tissue Specificity	Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. {ECO:0000269|PubMed:8566796}.
Top Pathways	MAPK signaling pathway, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human STK3 full length protein - ab195160 from Abcam Category Protein Prices $1,034.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human STK3 full length protein - ab60885 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human STK3 protein fragment - ab159602 from Abcam Category Protein Source Wheat germ Species Human

Human STK3 protein fragment - ab159603 from Abcam Category Protein Source Wheat germ Species Human

STK3 Antibody Blocking Peptide - LS-E3905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK3 Antibody Blocking Peptide - LS-E27836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK3 Antibody Blocking Peptide - LS-E17603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MST2/STK3 Recombinant Protein - H00006788-P01 from Novus Biologicals Category Protein Prices $539.00 Sizes 25 µg Species Human

MST2/STK3 Partial Recombinant Protein - H00006788-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

MST2/STK3 Partial Recombinant Protein - H00006788-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MST2/STK3 Recombinant Protein - P4234 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human MST2/STK3 Protein - P4727 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant MST2/STK3 Protein - NBP1-99481 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

MST2/STK3 Peptide - P2908 from Novus Biologicals Category Peptide Species Human

MST2-Antibody-C-term-Blocking-Peptide - BP7923a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STK3 (Active) recombinant protein - GTX65261 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

MST2 Blocking Peptide - 33R-10887 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

STK3 Blocking Peptide - 33R-3940 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

STK3 Blocking Peptide - 33R-5949 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

STK3 protein - 30R-2865 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

MST2 Blocking Peptide - abx063314 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

STK3 Peptide - AC21-2646-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

STK3 - H00006788-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

STK3 - H00006788-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

STK3 - H00006788-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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